Topical corn oil in the management of essential fatty acid deficiency

M. C. McCarthy; W. W. Turner; K. Whatley; G. L. Cottam

doi:10.1097/00003246-198305000-00011

Topical corn oil in the management of essential fatty acid deficiency

M. C. McCarthy, W. W. Turner, K. Whatley, G. L. Cottam

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Conflicting anecdotal reports about the efficacy of topical linoleate in managing essential fatty acid deficiency prompted this prospective study of 10 critically ill surgical patients receiving continuous total parenteral nutrition (TPN). Ten ml of corn oil (4800 mg of linoleate) were massaged into the skin daily commencing after 7.7 ± 3.8 (mean ± SD) days of fat-free intake. Plasma samples were obtained weekly. Total lipids were extracted and methylated, and fatty acids were quantitated by gas-liquid chromatography. The triene:tetraene ratio (20:3ω9/20:4ω6) increased progressively in patients despite corn oil therapy. In 89% of patients the ratio exceeded 0.2, which is diagnostic of essential fatty acid deficiency (EFAD). Topical application of corn oil does not prevent or treat EFAD in patients on TPN.

Original language	English (US)
Pages (from-to)	373-375
Number of pages	3
Journal	Critical care medicine
Volume	11
Issue number	5
DOIs	https://doi.org/10.1097/00003246-198305000-00011
State	Published - 1983

ASJC Scopus subject areas

Critical Care and Intensive Care Medicine

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title = "Topical corn oil in the management of essential fatty acid deficiency",

abstract = "Conflicting anecdotal reports about the efficacy of topical linoleate in managing essential fatty acid deficiency prompted this prospective study of 10 critically ill surgical patients receiving continuous total parenteral nutrition (TPN). Ten ml of corn oil (4800 mg of linoleate) were massaged into the skin daily commencing after 7.7 ± 3.8 (mean ± SD) days of fat-free intake. Plasma samples were obtained weekly. Total lipids were extracted and methylated, and fatty acids were quantitated by gas-liquid chromatography. The triene:tetraene ratio (20:3ω9/20:4ω6) increased progressively in patients despite corn oil therapy. In 89% of patients the ratio exceeded 0.2, which is diagnostic of essential fatty acid deficiency (EFAD). Topical application of corn oil does not prevent or treat EFAD in patients on TPN.",

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T1 - Topical corn oil in the management of essential fatty acid deficiency

AU - McCarthy, M. C.

AU - Turner, W. W.

AU - Whatley, K.

AU - Cottam, G. L.

PY - 1983

Y1 - 1983

N2 - Conflicting anecdotal reports about the efficacy of topical linoleate in managing essential fatty acid deficiency prompted this prospective study of 10 critically ill surgical patients receiving continuous total parenteral nutrition (TPN). Ten ml of corn oil (4800 mg of linoleate) were massaged into the skin daily commencing after 7.7 ± 3.8 (mean ± SD) days of fat-free intake. Plasma samples were obtained weekly. Total lipids were extracted and methylated, and fatty acids were quantitated by gas-liquid chromatography. The triene:tetraene ratio (20:3ω9/20:4ω6) increased progressively in patients despite corn oil therapy. In 89% of patients the ratio exceeded 0.2, which is diagnostic of essential fatty acid deficiency (EFAD). Topical application of corn oil does not prevent or treat EFAD in patients on TPN.

AB - Conflicting anecdotal reports about the efficacy of topical linoleate in managing essential fatty acid deficiency prompted this prospective study of 10 critically ill surgical patients receiving continuous total parenteral nutrition (TPN). Ten ml of corn oil (4800 mg of linoleate) were massaged into the skin daily commencing after 7.7 ± 3.8 (mean ± SD) days of fat-free intake. Plasma samples were obtained weekly. Total lipids were extracted and methylated, and fatty acids were quantitated by gas-liquid chromatography. The triene:tetraene ratio (20:3ω9/20:4ω6) increased progressively in patients despite corn oil therapy. In 89% of patients the ratio exceeded 0.2, which is diagnostic of essential fatty acid deficiency (EFAD). Topical application of corn oil does not prevent or treat EFAD in patients on TPN.

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Topical corn oil in the management of essential fatty acid deficiency

Abstract

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