Topical ciprofloxacin/dexamethasone otic suspension is superior to ofloxacin otic solution in the treatment of granulation tissue in children with acute otitis media with otorrhea through tympanostomy tubes

Peter S. Roland; Joseph E. Dohar; Brent J. Lanier; Robert Hekkenburg; Edward M. Lane; Peter J. Conroy; G. Michael Wall; Sheryl J. Dupre; Susan L. Potts

doi:10.1016/j.otohns.2004.02.037

Topical ciprofloxacin/dexamethasone otic suspension is superior to ofloxacin otic solution in the treatment of granulation tissue in children with acute otitis media with otorrhea through tympanostomy tubes

Peter S. Roland, Joseph E. Dohar, Brent J. Lanier, Robert Hekkenburg, Edward M. Lane, Peter J. Conroy, G. Michael Wall, Sheryl J. Dupre, Susan L. Potts

Otolaryngology - Head And Neck Surgery

Research output: Contribution to journal › Article › peer-review

47 Scopus citations

Abstract

Objective Comparison of topical ciprofloxacin/dexamethasone otic suspension (CIP/DEX) to ofloxacin otic solution (OFL) for treatment of granulation tissue in children with AOMT. Study design 599 children aged ≥6 months to 12 years with AOMT of up to 3 weeks' duration were enrolled. Patients received either CIP/DEX 4 drops twice daily for 7 days or OFL 5 drops twice daily for 10 days. Granulation tissue severity was graded at clinic visits on days 1, 3, 11, and 18. Results Granulation tissue was present in 90 of 599 AOMT patients (15.0%) at baseline. CIP/DEX treatment was superior to OFL for reduction of granulation tissue at the day 11 visit (81.3% compared with 56.1%, P = 0.0067) and the day 18 visit (91.7% compared with 73.2%, P = 0.0223). Both topical otic preparations are safe and well tolerated in pediatric patients. Conclusion CIP/DEX was superior to OFL in the treatment of granulation tissue in children with AOMT.

Original language	English (US)
Pages (from-to)	736-741
Number of pages	6
Journal	Otolaryngology - Head and Neck Surgery
Volume	130
Issue number	6
DOIs	https://doi.org/10.1016/j.otohns.2004.02.037
State	Published - Jun 2004

ASJC Scopus subject areas

Surgery
Otorhinolaryngology

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Roland, P. S., Dohar, J. E., Lanier, B. J., Hekkenburg, R., Lane, E. M., Conroy, P. J., Wall, G. M., Dupre, S. J., & Potts, S. L. (2004). Topical ciprofloxacin/dexamethasone otic suspension is superior to ofloxacin otic solution in the treatment of granulation tissue in children with acute otitis media with otorrhea through tympanostomy tubes. Otolaryngology - Head and Neck Surgery, 130(6), 736-741. https://doi.org/10.1016/j.otohns.2004.02.037

Topical ciprofloxacin/dexamethasone otic suspension is superior to ofloxacin otic solution in the treatment of granulation tissue in children with acute otitis media with otorrhea through tympanostomy tubes. / Roland, Peter S.; Dohar, Joseph E.; Lanier, Brent J. et al.
In: Otolaryngology - Head and Neck Surgery, Vol. 130, No. 6, 06.2004, p. 736-741.

Research output: Contribution to journal › Article › peer-review

Roland, PS, Dohar, JE, Lanier, BJ, Hekkenburg, R, Lane, EM, Conroy, PJ, Wall, GM, Dupre, SJ & Potts, SL 2004, 'Topical ciprofloxacin/dexamethasone otic suspension is superior to ofloxacin otic solution in the treatment of granulation tissue in children with acute otitis media with otorrhea through tympanostomy tubes', Otolaryngology - Head and Neck Surgery, vol. 130, no. 6, pp. 736-741. https://doi.org/10.1016/j.otohns.2004.02.037

Roland PS, Dohar JE, Lanier BJ, Hekkenburg R, Lane EM, Conroy PJ et al. Topical ciprofloxacin/dexamethasone otic suspension is superior to ofloxacin otic solution in the treatment of granulation tissue in children with acute otitis media with otorrhea through tympanostomy tubes. Otolaryngology - Head and Neck Surgery. 2004 Jun;130(6):736-741. doi: 10.1016/j.otohns.2004.02.037

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title = "Topical ciprofloxacin/dexamethasone otic suspension is superior to ofloxacin otic solution in the treatment of granulation tissue in children with acute otitis media with otorrhea through tympanostomy tubes",

abstract = "Objective Comparison of topical ciprofloxacin/dexamethasone otic suspension (CIP/DEX) to ofloxacin otic solution (OFL) for treatment of granulation tissue in children with AOMT. Study design 599 children aged ≥6 months to 12 years with AOMT of up to 3 weeks' duration were enrolled. Patients received either CIP/DEX 4 drops twice daily for 7 days or OFL 5 drops twice daily for 10 days. Granulation tissue severity was graded at clinic visits on days 1, 3, 11, and 18. Results Granulation tissue was present in 90 of 599 AOMT patients (15.0%) at baseline. CIP/DEX treatment was superior to OFL for reduction of granulation tissue at the day 11 visit (81.3% compared with 56.1%, P = 0.0067) and the day 18 visit (91.7% compared with 73.2%, P = 0.0223). Both topical otic preparations are safe and well tolerated in pediatric patients. Conclusion CIP/DEX was superior to OFL in the treatment of granulation tissue in children with AOMT.",

author = "Roland, {Peter S.} and Dohar, {Joseph E.} and Lanier, {Brent J.} and Robert Hekkenburg and Lane, {Edward M.} and Conroy, {Peter J.} and Wall, {G. Michael} and Dupre, {Sheryl J.} and Potts, {Susan L.}",

note = "Funding Information: This study was supported by a grant from Alcon Research Ltd., Fort Worth, TX (ARL). Dr Roland is an independent physician who provides paid medical monitor and/or advisor services to ARL. Drs Dohar, Lanier, Hekkenburg, and Lane are independent physicians with no conflict of interest or other financial arrangements with ARL. The remaining authors are all Alcon employees. ",

year = "2004",

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doi = "10.1016/j.otohns.2004.02.037",

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AU - Roland, Peter S.

AU - Dohar, Joseph E.

AU - Lanier, Brent J.

AU - Hekkenburg, Robert

AU - Lane, Edward M.

AU - Conroy, Peter J.

AU - Wall, G. Michael

AU - Dupre, Sheryl J.

AU - Potts, Susan L.

N1 - Funding Information: This study was supported by a grant from Alcon Research Ltd., Fort Worth, TX (ARL). Dr Roland is an independent physician who provides paid medical monitor and/or advisor services to ARL. Drs Dohar, Lanier, Hekkenburg, and Lane are independent physicians with no conflict of interest or other financial arrangements with ARL. The remaining authors are all Alcon employees.

PY - 2004/6

Y1 - 2004/6

N2 - Objective Comparison of topical ciprofloxacin/dexamethasone otic suspension (CIP/DEX) to ofloxacin otic solution (OFL) for treatment of granulation tissue in children with AOMT. Study design 599 children aged ≥6 months to 12 years with AOMT of up to 3 weeks' duration were enrolled. Patients received either CIP/DEX 4 drops twice daily for 7 days or OFL 5 drops twice daily for 10 days. Granulation tissue severity was graded at clinic visits on days 1, 3, 11, and 18. Results Granulation tissue was present in 90 of 599 AOMT patients (15.0%) at baseline. CIP/DEX treatment was superior to OFL for reduction of granulation tissue at the day 11 visit (81.3% compared with 56.1%, P = 0.0067) and the day 18 visit (91.7% compared with 73.2%, P = 0.0223). Both topical otic preparations are safe and well tolerated in pediatric patients. Conclusion CIP/DEX was superior to OFL in the treatment of granulation tissue in children with AOMT.

AB - Objective Comparison of topical ciprofloxacin/dexamethasone otic suspension (CIP/DEX) to ofloxacin otic solution (OFL) for treatment of granulation tissue in children with AOMT. Study design 599 children aged ≥6 months to 12 years with AOMT of up to 3 weeks' duration were enrolled. Patients received either CIP/DEX 4 drops twice daily for 7 days or OFL 5 drops twice daily for 10 days. Granulation tissue severity was graded at clinic visits on days 1, 3, 11, and 18. Results Granulation tissue was present in 90 of 599 AOMT patients (15.0%) at baseline. CIP/DEX treatment was superior to OFL for reduction of granulation tissue at the day 11 visit (81.3% compared with 56.1%, P = 0.0067) and the day 18 visit (91.7% compared with 73.2%, P = 0.0223). Both topical otic preparations are safe and well tolerated in pediatric patients. Conclusion CIP/DEX was superior to OFL in the treatment of granulation tissue in children with AOMT.

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Topical ciprofloxacin/dexamethasone otic suspension is superior to ofloxacin otic solution in the treatment of granulation tissue in children with acute otitis media with otorrhea through tympanostomy tubes

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