Toll-like receptors: Balancing host resistance with immune tolerance

Chandrashekhar Pasare, Ruslan Medzhitov

Research output: Contribution to journalReview articlepeer-review

115 Scopus citations


Recent advances in the field of Toll-like receptors (TLRs) have established their importance for acute innate immune responses and their fundamental requirement for initiation of CD4+ T-cell responses. Current directions in the field have been towards understanding the role of cytokines secreted by professional antigen-presenting cells in response to TLR ligands and also pathological manifestations in terms of increased production of rheumatoid factors due to TLR ligation on B cells. Thus, it is becoming clear that TLRs are important for induction of adaptive immune responses, but misguided responses can lead to autoimmune pathology.

Original languageEnglish (US)
Pages (from-to)677-682
Number of pages6
JournalCurrent Opinion in Immunology
Issue number6
StatePublished - Dec 2003

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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