TY - JOUR
T1 - Toll-like receptors
T2 - Balancing host resistance with immune tolerance
AU - Pasare, Chandrashekhar
AU - Medzhitov, Ruslan
PY - 2003/12
Y1 - 2003/12
N2 - Recent advances in the field of Toll-like receptors (TLRs) have established their importance for acute innate immune responses and their fundamental requirement for initiation of CD4+ T-cell responses. Current directions in the field have been towards understanding the role of cytokines secreted by professional antigen-presenting cells in response to TLR ligands and also pathological manifestations in terms of increased production of rheumatoid factors due to TLR ligation on B cells. Thus, it is becoming clear that TLRs are important for induction of adaptive immune responses, but misguided responses can lead to autoimmune pathology.
AB - Recent advances in the field of Toll-like receptors (TLRs) have established their importance for acute innate immune responses and their fundamental requirement for initiation of CD4+ T-cell responses. Current directions in the field have been towards understanding the role of cytokines secreted by professional antigen-presenting cells in response to TLR ligands and also pathological manifestations in terms of increased production of rheumatoid factors due to TLR ligation on B cells. Thus, it is becoming clear that TLRs are important for induction of adaptive immune responses, but misguided responses can lead to autoimmune pathology.
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U2 - 10.1016/j.coi.2003.09.002
DO - 10.1016/j.coi.2003.09.002
M3 - Review article
C2 - 14630202
AN - SCOPUS:0242556891
SN - 0952-7915
VL - 15
SP - 677
EP - 682
JO - Current Opinion in Immunology
JF - Current Opinion in Immunology
IS - 6
ER -