Time-kill studies of antibiotic combinations against penicillin-resistant and -susceptible streptococcus pneumoniae

Ian R. Friedland, Maria Paris, Sharon Shelton, George H. Mccracken

Research output: Contribution to journalArticlepeer-review

48 Scopus citations


Time-kill studies were conducted to evaluate antibiotic combinations against four strains of Streptococcus pneumoniae for which the MICs of penicillin were 0.03, 0.25, 1 and 4 mg/L, respectively. After 8 h of antibiotic exposure the combination of ceftriaxone and vancomycin showed enhanced activity against all four strains. Penicillin plus vancomycin and ceftriaxone plus gentamicin showed enhanced activity against the three penicillin-resistant strains. Combinations of vancomycin and rifampicin were indifferent. These results are similar to those found previously in the rabbit meningitis model suggesting that time-kill studies over 8 h may be useful in predicting in-vivo antibiotic interactions in resistant pneumococcal infections.

Original languageEnglish (US)
Pages (from-to)231-237
Number of pages7
JournalJournal of Antimicrobial Chemotherapy
Issue number2
StatePublished - Aug 1994

ASJC Scopus subject areas

  • Pharmacology
  • Microbiology (medical)
  • Infectious Diseases
  • Pharmacology (medical)


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