Thymosin β4 sustained release from poly(lactide-co-glycolide) microspheres: Synthesis and implications for treatment of myocardial ischemia

Jeffrey E. Thatcher; Tré Welch; Robert C. Eberhart; Zoltan A. Schelly; J. Michael Dimaio

doi:10.1111/j.1749-6632.2012.06681.x

Thymosin β4 sustained release from poly(lactide-co-glycolide) microspheres: Synthesis and implications for treatment of myocardial ischemia

Jeffrey E. Thatcher, Tré Welch, Robert C. Eberhart, Zoltan A. Schelly, J. Michael Dimaio

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

A sustained release formulation for the therapeutic peptide thymosin β4 (Tβ4) that can be localized to the heart and reduce the concentration and frequency of dose is being explored as a means to improve its delivery in humans. This review contains concepts involved in the delivery of peptides to the heart and the synthesis of polymer microspheres for the sustained release of peptides, including Tβ4. Initial results of poly(lactic-co-glycolic acid) microspheres synthesized with specific tolerances for intramyocardial injection that demonstrate the encapsulation and release of Tβ4 from double-emulsion microspheres are also presented.

Original language	English (US)
Pages (from-to)	112-119
Number of pages	8
Journal	Annals of the New York Academy of Sciences
Volume	1270
Issue number	1
DOIs	https://doi.org/10.1111/j.1749-6632.2012.06681.x
State	Published - Oct 2012

Keywords

Controlled
Heart
Microsphere
Release
Sustained
Thymosin β4

ASJC Scopus subject areas

Neuroscience(all)
Biochemistry, Genetics and Molecular Biology(all)
History and Philosophy of Science

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10.1111/j.1749-6632.2012.06681.x

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abstract = "A sustained release formulation for the therapeutic peptide thymosin β4 (Tβ4) that can be localized to the heart and reduce the concentration and frequency of dose is being explored as a means to improve its delivery in humans. This review contains concepts involved in the delivery of peptides to the heart and the synthesis of polymer microspheres for the sustained release of peptides, including Tβ4. Initial results of poly(lactic-co-glycolic acid) microspheres synthesized with specific tolerances for intramyocardial injection that demonstrate the encapsulation and release of Tβ4 from double-emulsion microspheres are also presented.",

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AU - Schelly, Zoltan A.

AU - Michael Dimaio, J.

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KW - Sustained

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Thymosin β4 sustained release from poly(lactide-co-glycolide) microspheres: Synthesis and implications for treatment of myocardial ischemia

Abstract

Keywords

ASJC Scopus subject areas

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