TY - JOUR
T1 - Thrombosis during infancy and childhood
T2 - What we know and what we do not know
AU - Journeycake, Janna M.
AU - Manco-Johnson, Marilyn J.
N1 - Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 2004/12
Y1 - 2004/12
N2 - The mean age of adults who have venous thrombosis is the sixth to eighth decade of life. Many adults who have thrombosis have significant underlying illnesses (eg, cardiac disease, cancer) that decrease life expectancy. Conversely, despite underlying illnesses, children have a greater chance to survive and are expected to live 6 to 8 decades following an episode of venous or arterial thrombosis. The disproportionate benefits of preventing thrombosis and its sequelae in pediatric patients are evident. Therefore, it is necessary to develop appropriate strategies for diagnosis and management of thromboembolic events in children and to understand their acute and long-term effects. There are many unanswered questions, so clinical trials are being designed to help study these important issues.
AB - The mean age of adults who have venous thrombosis is the sixth to eighth decade of life. Many adults who have thrombosis have significant underlying illnesses (eg, cardiac disease, cancer) that decrease life expectancy. Conversely, despite underlying illnesses, children have a greater chance to survive and are expected to live 6 to 8 decades following an episode of venous or arterial thrombosis. The disproportionate benefits of preventing thrombosis and its sequelae in pediatric patients are evident. Therefore, it is necessary to develop appropriate strategies for diagnosis and management of thromboembolic events in children and to understand their acute and long-term effects. There are many unanswered questions, so clinical trials are being designed to help study these important issues.
UR - http://www.scopus.com/inward/record.url?scp=7044224583&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=7044224583&partnerID=8YFLogxK
U2 - 10.1016/j.hoc.2004.07.001
DO - 10.1016/j.hoc.2004.07.001
M3 - Review article
C2 - 15511618
AN - SCOPUS:7044224583
SN - 0889-8588
VL - 18
SP - 1315
EP - 1338
JO - Hematology/Oncology Clinics of North America
JF - Hematology/Oncology Clinics of North America
IS - 6 SPEC.ISS.
ER -