Thrombosis and a hypercoagulable state in HIV-infected patients

Yu Min P Shen, Eugene P. Frenkel

Research output: Contribution to journalArticlepeer-review

92 Scopus citations


Human immunodeficiency virus infection is an illness with protean manifestations including hematological abnormalities. Thromboembolic complications in HIV-infected patients have been described. Recent literature describes an incidence ranging from 0.26% to 7.6%; higher incidence is seen in patients with active opportunistic infections or malignancy, and in patients with the acquired immunodeficiency syndrome. A variety of potential mechanisms have been proposed to account for the observed hypercoagulability in HIV-infected patients. These include the presence of antiphospholipid- anticardiolipin antibodies, decreased activities of natural anticoagulants (especially protein S), and increased platelet activation. Recent epidemiological studies emphasize the increased incidence of thromboembolic events including myocardial infarction in the HIV-infected population after the introduction of highly active antiretroviral therapy. The use of protease inhibitors in particular is implicated. A hypercoagulable state and especially thromboses are emerging as clinical issues in HIV-infected patients. Further studies are in order to more clearly delineate the pathophysiologic mechanism(s) of thromboses in HIV-infected patients.

Original languageEnglish (US)
Pages (from-to)277-280
Number of pages4
JournalClinical and Applied Thrombosis/Hemostasis
Issue number3
StatePublished - Jul 2004


  • Acquired immunodeficiency syndrome
  • Highly active antiretroviral therapy
  • Human immunodeficiency virus
  • Hypercoagulable state
  • Opportunistic infections
  • Platelet activation
  • Protease inhibitors
  • Protein S deficiency

ASJC Scopus subject areas

  • Hematology


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