Thrombocytopenia: Issues in diagnosis and therapy

C. J. Rutherford, E. P. Frenkel

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


Thrombocytopenia is defined by clinical characteristics and pathophysiologic mechanisms. The patient with thrombocytopenia often presents diagnostic and management challenges simultaneously. The differential diagnosis is broad because the disorders leading to thrombocytopenia are diverse, with failed production at one extreme and accelerated destruction at the other. Reviewed in terms of diagnosis and therapy are pseudothrombocytopenia, dilutional thrombocytopenia, and the three major mechanisms: decreased production, altered distribution, and increased destruction.

Original languageEnglish (US)
Pages (from-to)555-575
Number of pages21
JournalMedical Clinics of North America
Issue number3
StatePublished - 1994

ASJC Scopus subject areas

  • Medicine(all)


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