Three-dimensional printed modeling of diffuse low-grade gliomas and associated white matter tract anatomy

Jayesh P. Thawani; Nickpreet Singh; Jared M. Pisapia; Kalil G. Abdullah; Drew Parker; Bryan A. Pukenas; Eric L. Zager; Ragini Verma; Steven Brem

doi:10.1093/neuros/nyx009

Three-dimensional printed modeling of diffuse low-grade gliomas and associated white matter tract anatomy

Jayesh P. Thawani, Nickpreet Singh, Jared M. Pisapia, Kalil G. Abdullah, Drew Parker, Bryan A. Pukenas, Eric L. Zager, Ragini Verma, Steven Brem

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

BACKGROUND: Diffuse low-grade gliomas (DLGGs) represent several pathological entities that infiltrate and invade cortical and subcortical structures in the brain. OBJECTIVE: To describe methods for rapid prototyping of DLGGs and surgically relevant anatomy. METHODS: Using high-definition imaging data and rapid prototyping technologies, we were able to generate 3 patient DLGGs to scale and represent the associated white matter tracts in 3 dimensions using advanced diffusion tensor imaging techniques. RESULTS: This report represents a novel application of 3-dimensional (3-D) printing in neurosurgery and a means to model individualized tumors in 3-D space with respect to subcortical white matter tract anatomy. Faculty and resident evaluations of this technology were favorable at our institution. CONCLUSION: Developing an understanding of the anatomic relationships existing within individuals is fundamental to successful neurosurgical therapy. Imaging-based rapid prototyping may improve on our ability to plan for and treat complex neuro-oncologic pathology.

Original language	English (US)
Pages (from-to)	635-645
Number of pages	11
Journal	Clinical neurosurgery
Volume	80
Issue number	4
DOIs	https://doi.org/10.1093/neuros/nyx009
State	Published - Apr 1 2017
Externally published	Yes

Keywords

3-D printing
Brain tumor modeling
Diffusion tensor imaging

ASJC Scopus subject areas

Surgery
Clinical Neurology

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10.1093/neuros/nyx009

Cite this

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title = "Three-dimensional printed modeling of diffuse low-grade gliomas and associated white matter tract anatomy",

abstract = "BACKGROUND: Diffuse low-grade gliomas (DLGGs) represent several pathological entities that infiltrate and invade cortical and subcortical structures in the brain. OBJECTIVE: To describe methods for rapid prototyping of DLGGs and surgically relevant anatomy. METHODS: Using high-definition imaging data and rapid prototyping technologies, we were able to generate 3 patient DLGGs to scale and represent the associated white matter tracts in 3 dimensions using advanced diffusion tensor imaging techniques. RESULTS: This report represents a novel application of 3-dimensional (3-D) printing in neurosurgery and a means to model individualized tumors in 3-D space with respect to subcortical white matter tract anatomy. Faculty and resident evaluations of this technology were favorable at our institution. CONCLUSION: Developing an understanding of the anatomic relationships existing within individuals is fundamental to successful neurosurgical therapy. Imaging-based rapid prototyping may improve on our ability to plan for and treat complex neuro-oncologic pathology.",

keywords = "3-D printing, Brain tumor modeling, Diffusion tensor imaging",

author = "Thawani, {Jayesh P.} and Nickpreet Singh and Pisapia, {Jared M.} and Abdullah, {Kalil G.} and Drew Parker and Pukenas, {Bryan A.} and Zager, {Eric L.} and Ragini Verma and Steven Brem",

note = "Funding Information: This research was supported by grants from the National Institutes of Health (RO1 NS096606; principal investigators Drs Verma and Brem), and the Chera Family Foundation (Brain Mapping Grant, principal investigator Dr Brem). The authors have no personal, financial, or institutional interest in any of the drugs, materials, or devices described in this article. Publisher Copyright: Copyright {\textcopyright} 2017 by the Congress of Neurological Surgeons.",

year = "2017",

month = apr,

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doi = "10.1093/neuros/nyx009",

language = "English (US)",

volume = "80",

pages = "635--645",

journal = "Clinical neurosurgery",

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publisher = "Lippincott Williams and Wilkins",

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T1 - Three-dimensional printed modeling of diffuse low-grade gliomas and associated white matter tract anatomy

AU - Thawani, Jayesh P.

AU - Singh, Nickpreet

AU - Pisapia, Jared M.

AU - Abdullah, Kalil G.

AU - Parker, Drew

AU - Pukenas, Bryan A.

AU - Zager, Eric L.

AU - Verma, Ragini

AU - Brem, Steven

N1 - Funding Information: This research was supported by grants from the National Institutes of Health (RO1 NS096606; principal investigators Drs Verma and Brem), and the Chera Family Foundation (Brain Mapping Grant, principal investigator Dr Brem). The authors have no personal, financial, or institutional interest in any of the drugs, materials, or devices described in this article. Publisher Copyright: Copyright © 2017 by the Congress of Neurological Surgeons.

PY - 2017/4/1

Y1 - 2017/4/1

N2 - BACKGROUND: Diffuse low-grade gliomas (DLGGs) represent several pathological entities that infiltrate and invade cortical and subcortical structures in the brain. OBJECTIVE: To describe methods for rapid prototyping of DLGGs and surgically relevant anatomy. METHODS: Using high-definition imaging data and rapid prototyping technologies, we were able to generate 3 patient DLGGs to scale and represent the associated white matter tracts in 3 dimensions using advanced diffusion tensor imaging techniques. RESULTS: This report represents a novel application of 3-dimensional (3-D) printing in neurosurgery and a means to model individualized tumors in 3-D space with respect to subcortical white matter tract anatomy. Faculty and resident evaluations of this technology were favorable at our institution. CONCLUSION: Developing an understanding of the anatomic relationships existing within individuals is fundamental to successful neurosurgical therapy. Imaging-based rapid prototyping may improve on our ability to plan for and treat complex neuro-oncologic pathology.

AB - BACKGROUND: Diffuse low-grade gliomas (DLGGs) represent several pathological entities that infiltrate and invade cortical and subcortical structures in the brain. OBJECTIVE: To describe methods for rapid prototyping of DLGGs and surgically relevant anatomy. METHODS: Using high-definition imaging data and rapid prototyping technologies, we were able to generate 3 patient DLGGs to scale and represent the associated white matter tracts in 3 dimensions using advanced diffusion tensor imaging techniques. RESULTS: This report represents a novel application of 3-dimensional (3-D) printing in neurosurgery and a means to model individualized tumors in 3-D space with respect to subcortical white matter tract anatomy. Faculty and resident evaluations of this technology were favorable at our institution. CONCLUSION: Developing an understanding of the anatomic relationships existing within individuals is fundamental to successful neurosurgical therapy. Imaging-based rapid prototyping may improve on our ability to plan for and treat complex neuro-oncologic pathology.

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Three-dimensional printed modeling of diffuse low-grade gliomas and associated white matter tract anatomy

Abstract

Keywords

ASJC Scopus subject areas

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