TY - JOUR
T1 - “They were already inside my head to begin with”
T2 - Trust, Translational Misconception, and Intraoperative Brain Research
AU - Peabody Smith, Ally
AU - Taiclet, Lauren
AU - Ebadi, Hamasa
AU - Levy, Lilyana
AU - Weber, Megan
AU - Caruso, Eugene M.
AU - Pouratian, Nader
AU - Feinsinger, Ashley
N1 - Funding Information:
This project was funded by NIH BRAIN Initiative grant RF1MH121373. The authors would like to acknowledge the attendees at the 2021 International Neuroethics Society Meeting, the 2022 NIH BRAIN Initiative Neuroethics Working Group Meeting, and the UCLA TNT Faculty Seminar series for insightful discussion of the data presented in this paper. Special thanks to Michelle Pham, who assisted with data collection, two anonymous reviewers for this journal, and the participants who offered their time.
Funding Information:
The authors do not have any financial conflicts of interest with this project. NP is a consultant for Abbot Laboratories, and NP, AF, and EC receive grant support from NIH BRAIN Initiative RF1MH121373. Funders had no role in the development of this study.
Publisher Copyright:
© 2022 Taylor & Francis Group, LLC.
PY - 2023
Y1 - 2023
N2 - Background: Patients undergoing invasive neurosurgical procedures offer researchers unique opportunities to study the brain. Deep brain stimulation patients, for example, may participate in research during the surgical implantation of the stimulator device. Although this research raises many ethical concerns, little attention has been paid to basic studies, which offer no therapeutic benefits, and the value of patient-participant perspectives. Methods: Semi-structured interviews were conducted with fourteen individuals across two studies who participated in basic intraoperative research during their deep brain stimulator surgery. Interviews explored interpretations of risks and benefits, enrollment motivations, and experiences of participating in awake brain research. Reflexive thematic analysis was conducted. Results: Seven themes were identified from participant narratives, including robust attitudes of trust, high valuations of basic science research, impacts of the surgical context, and mixed experiences of participation. Conclusion: We argue that these narratives raise the potential for a translational misconception and motivate intraoperative re-consent procedures.
AB - Background: Patients undergoing invasive neurosurgical procedures offer researchers unique opportunities to study the brain. Deep brain stimulation patients, for example, may participate in research during the surgical implantation of the stimulator device. Although this research raises many ethical concerns, little attention has been paid to basic studies, which offer no therapeutic benefits, and the value of patient-participant perspectives. Methods: Semi-structured interviews were conducted with fourteen individuals across two studies who participated in basic intraoperative research during their deep brain stimulator surgery. Interviews explored interpretations of risks and benefits, enrollment motivations, and experiences of participating in awake brain research. Reflexive thematic analysis was conducted. Results: Seven themes were identified from participant narratives, including robust attitudes of trust, high valuations of basic science research, impacts of the surgical context, and mixed experiences of participation. Conclusion: We argue that these narratives raise the potential for a translational misconception and motivate intraoperative re-consent procedures.
KW - Research ethics
KW - deep brain stimulation
KW - informed consent
KW - neurosurgery
KW - participant perspectives
KW - translational misconception
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U2 - 10.1080/23294515.2022.2123869
DO - 10.1080/23294515.2022.2123869
M3 - Article
C2 - 36137012
AN - SCOPUS:85139144445
SN - 2329-4515
VL - 14
SP - 111
EP - 124
JO - AJOB Empirical Bioethics
JF - AJOB Empirical Bioethics
IS - 2
ER -