TY - JOUR
T1 - Therapeutic manipulation of T cell chemotaxis in transplantation
AU - Yopp, Adam C.
AU - Krieger, Nancy R.
AU - Ochando, Jordi C.
AU - Bromberg, Jonathan S.
N1 - Funding Information:
The authors thank the National Institutes of Health and the Juvenile Diabetes Research Foundation International for research support.
Copyright:
Copyright 2012 Elsevier B.V., All rights reserved.
PY - 2004/10
Y1 - 2004/10
N2 - T cell migration and trafficking are regulated by the well defined cellular processes of rolling, activation, tight adhesion, arrest and diapedesis. These processes are, in turn, controlled by molecular events involving integrins, selectins, chemokines and chemokine receptors. Recent studies have shown that sphingosine 1-phosphate receptors and their ligands are also important molecular modulators of migration and trafficking. Many of these molecules are appropriate targets for preventing allograft rejection or for achieving tolerance. Studies of migration and trafficking have also shown that the anatomic choreography of alloantigen presentation and T cell encounter with alloantigen and immunosuppression, are over-riding determinants of T cell priming versus tolerization.
AB - T cell migration and trafficking are regulated by the well defined cellular processes of rolling, activation, tight adhesion, arrest and diapedesis. These processes are, in turn, controlled by molecular events involving integrins, selectins, chemokines and chemokine receptors. Recent studies have shown that sphingosine 1-phosphate receptors and their ligands are also important molecular modulators of migration and trafficking. Many of these molecules are appropriate targets for preventing allograft rejection or for achieving tolerance. Studies of migration and trafficking have also shown that the anatomic choreography of alloantigen presentation and T cell encounter with alloantigen and immunosuppression, are over-riding determinants of T cell priming versus tolerization.
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U2 - 10.1016/j.coi.2004.07.003
DO - 10.1016/j.coi.2004.07.003
M3 - Review article
C2 - 15342001
AN - SCOPUS:4444362843
SN - 0952-7915
VL - 16
SP - 571
EP - 577
JO - Current Opinion in Immunology
JF - Current Opinion in Immunology
IS - 5
ER -