Therapeutic implications of dopamine D4 vs. D2 receptor selectivity and occupancy

R. A. Lahti, G. S. Gill, C. A. Tamminga, D. L. Evans, N. C. Stratman, L. M. Figur

Research output: Contribution to journalArticlepeer-review


Clozapine and melperone exhibit higher affinity for the dopamine D4 receptor than the D2 receptor. Raclopride and chlorpromazine exhibit high selectivity for the dopamine D2 receptor. D4 selective compounds have a low incidence of EPS and TD, whereas D2 selective compounds have a higher incidence. It is postulated that a drug's affinity for the D4 receptor may confer antipsychotic activity and its affinity for the D2 receptor may confer EPS and/or TD activity.

Original languageEnglish (US)
Pages (from-to)234-236
Number of pages3
JournalEuropean Neuropsychopharmacology
Issue number3
StatePublished - Sep 1993


  • Antipsychotic
  • Dopamine D
  • Dopamine D
  • Dyskinesia
  • Extrapyramidal

ASJC Scopus subject areas

  • Pharmacology
  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health
  • Biological Psychiatry
  • Pharmacology (medical)


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