@article{c999de897fc7454f8da7f8791a070997,
title = "Therapeutic escape in gaq-mutant uveal melanoma: It's a FAK",
abstract = "Through a synthetic lethal screen, ERK activation was found to mediate resistance to FAK inhibition in GNAQ-mutant uveal melanoma. With PLCB-PKC-ERK and Trio-FAK-Yap representing compensatory effectors of mutant Gaq signaling, combined inhibition of both pathways may be a promising therapeutic strategy in metastatic uveal melanoma.",
author = "Harbour, {J. William}",
note = "Funding Information: This study was supported by NIH grants R01 CA125970 (to J. William Harbour), P30CA240139 (Sylvester Comprehensive Cancer Center), and NEI P30EY014801 (Bascom Palmer Eye Institute), Research to Prevent Blindness Unrestricted Grant (Bascom Palmer Eye Institute), Department of Defense grant W81XWH-15-1-0578 (to J. William Harbour), Research to Prevent Blindness, Inc. Senior Scientific Investigator Award (to J. William Harbour), and a generous gift from Mark J. Daily (J. William Harbour). Publisher Copyright: {\textcopyright} 2021 American Association for Cancer Research.",
year = "2021",
month = jun,
day = "1",
doi = "10.1158/1078-0432.CCR-21-0567",
language = "English (US)",
volume = "27",
pages = "2967--2969",
journal = "Clinical Cancer Research",
issn = "1078-0432",
publisher = "American Association for Cancer Research Inc.",
number = "11",
}