Therapeutic escape in gaq-mutant uveal melanoma: It's a FAK

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4 Scopus citations


Through a synthetic lethal screen, ERK activation was found to mediate resistance to FAK inhibition in GNAQ-mutant uveal melanoma. With PLCB-PKC-ERK and Trio-FAK-Yap representing compensatory effectors of mutant Gaq signaling, combined inhibition of both pathways may be a promising therapeutic strategy in metastatic uveal melanoma.

Original languageEnglish (US)
Pages (from-to)2967-2969
Number of pages3
JournalClinical Cancer Research
Issue number11
StatePublished - Jun 1 2021
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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