Theophylline toxicity in a premature neonate - Elimination kinetics of exchange transfusion

Harold H. Osborn, Glendon Henry, Paul Wax, Robert Hoffman, Mary Ann Howland

Research output: Contribution to journalComment/debatepeer-review

17 Scopus citations


Exchange transfusion was utilized in the treatment of a 1871 gram female, 32 weeks gestational age, who received an IV bolus of aminophylline at 11 h for the treatment of apnea, with subsequent tachycardia and hypotension. At 22 h, plasma theophylline was 369.29 μmol/L (67 mg/L). During a single volume exchange transfusion at 33 h, the plasma theophylline decreased 19% and the estimated removal of theophylline was 13.5% of the whole body theophylline. The theophylline apparent half-times before, during, and after the exchange were 52.5, 6.6, and 53.3 h respectively.

Original languageEnglish (US)
Pages (from-to)639-644
Number of pages6
JournalClinical Toxicology
Issue number4
StatePublished - Jan 1 1993


  • Exchange transfusion
  • Pharmacokinetics
  • Premature infant
  • Theophylline
  • Toxicity

ASJC Scopus subject areas

  • Toxicology


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