Abstract
Maintaining genomic stability is critical for the prevention of disease. Numerous DNA repair pathways help to maintain genomic stability by correcting potentially lethal or disease-causing lesions to our genomes. Mounting evidence suggests that the post-translational modification sumoylation plays an important regulatory role in several aspects of DNA repair. The E3 SUMO ligase MMS21/NSE2 has gained increasing attention for its function in homologous recombination (HR), an error-free DNA repair pathway that mediates repair of double-strand breaks (DSBs) using the sister chromatid as a repair template. MMS21/NSE2 is part of the SMC5/6 complex, which has been shown to facilitate DSB repair, collapsed replication fork restart, and telomere elongation by HR. Here, I review the function of the SMC5/6 complex and its associated MMS21/NSE2 SUMO ligase activity in homologous recombination.
Original language | English (US) |
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Pages (from-to) | 499-506 |
Number of pages | 8 |
Journal | DNA repair |
Volume | 8 |
Issue number | 4 |
DOIs | |
State | Published - Apr 5 2009 |
Keywords
- DNA repair
- Homologous recombination
- MMS21
- NSE2
- SMC5
- SMC6
- SUMO
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Cell Biology