The yeast metabolic cycle: Insights into the life of a eukaryotic cell

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25 Scopus citations


The budding yeast Saccharomyces cerevisiae undergoes robust oscillations in oxygen consumption during continuous growth under nutrient-limited conditions. Comprehensive microarray studies reveal that more than half of the yeast genome is expressed periodically as a function of these respiratory oscillations, thereby specifying an extensively orchestrated program responsible for regulating numerous cellular outputs. Here, we summarize the logic of the yeast metabolic cycle (YMC) and highlight additional cellular processes that are predicted to be compartmentalized in time. Certain principles of temporal orchestration as seen during the YMC might be conserved across other biological cycles.

Original languageEnglish (US)
Pages (from-to)339-343
Number of pages5
JournalCold Spring Harbor symposia on quantitative biology
StatePublished - 2007

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Genetics


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