The WAVE regulatory complex is inhibited

Ayman M. Ismail, Shae B. Padrick, Baoyu Chen, Junko Umetani, Michael K. Rosen

Research output: Contribution to journalArticlepeer-review

116 Scopus citations


The WAVE regulatory complex (WRC) transmits information from the Rac GTPase to the actin nucleator Arp2/3 complex. We have reconstituted recombinant human and Drosophila WRC in several forms and shown that they are inactive toward Arp2/3 complex but can be activated by Rac in a nucleotide-dependent fashion. Our observations identify core components needed for WAVE inhibition, reconcile contradictory existing mechanisms and reveal common regulatory principles for the WAVE/WASP family of proteins.

Original languageEnglish (US)
Pages (from-to)561-563
Number of pages3
JournalNature Structural and Molecular Biology
Issue number5
StatePublished - May 2009

ASJC Scopus subject areas

  • Structural Biology
  • Molecular Biology


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