The use of placebo controls

C. Schechter, S. Gagliano, G. Traversa, H. R. Taylor, S. D. Nash, E. M. Gilbert, M. Packer, T. J M Cleophas, R. Pohl, R. Balon, W. F. Denny, J. J. Sramek, N. R. Cutler, D. A. Solomon, K. J. Rothman, K. B. Michels

Research output: Contribution to journalLetterpeer-review

1 Scopus citations


To the Editor: Rothman and Michels (Aug. 11 issue)1 object to the practice of giving “individual investigators and… institutional review boards the right to determine how much discomfort or temporary disability patients should endure for the purpose of research.” Regardless of what controls are used, precisely such a determination must be made concerning the foreseeable adverse effects of the treatment under study and the observation procedures. Is it really worse to ask an informed patient to volunteer to forgo treatment of mild hypertension for a few weeks than to ask a research subject to undergo a radiologic…

Original languageEnglish (US)
Pages (from-to)60-62
Number of pages3
JournalNew England Journal of Medicine
Issue number1
StatePublished - Jan 5 1995

ASJC Scopus subject areas

  • Medicine(all)


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