The use of placebo controls

C. Schechter; S. Gagliano; G. Traversa; H. R. Taylor; S. D. Nash; E. M. Gilbert; M. Packer; T. J M Cleophas; R. Pohl; R. Balon; W. F. Denny; J. J. Sramek; N. R. Cutler; D. A. Solomon; K. J. Rothman; K. B. Michels

doi:10.1056/NEJM199501053320114

The use of placebo controls

C. Schechter, S. Gagliano, G. Traversa, H. R. Taylor, S. D. Nash, E. M. Gilbert, M. Packer, T. J M Cleophas, R. Pohl, R. Balon, W. F. Denny, J. J. Sramek, N. R. Cutler, D. A. Solomon, K. J. Rothman, K. B. Michels

Clinical Sciences

Research output: Contribution to journal › Letter › peer-review

1 Scopus citations

Abstract

To the Editor: Rothman and Michels (Aug. 11 issue)¹ object to the practice of giving “individual investigators and… institutional review boards the right to determine how much discomfort or temporary disability patients should endure for the purpose of research.” Regardless of what controls are used, precisely such a determination must be made concerning the foreseeable adverse effects of the treatment under study and the observation procedures. Is it really worse to ask an informed patient to volunteer to forgo treatment of mild hypertension for a few weeks than to ask a research subject to undergo a radiologic…

Original language	English (US)
Pages (from-to)	60-62
Number of pages	3
Journal	New England Journal of Medicine
Volume	332
Issue number	1
DOIs	https://doi.org/10.1056/NEJM199501053320114
State	Published - Jan 5 1995

ASJC Scopus subject areas

Medicine(all)

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10.1056/NEJM199501053320114

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title = "The use of placebo controls",

abstract = "To the Editor: Rothman and Michels (Aug. 11 issue)1 object to the practice of giving “individual investigators and… institutional review boards the right to determine how much discomfort or temporary disability patients should endure for the purpose of research.” Regardless of what controls are used, precisely such a determination must be made concerning the foreseeable adverse effects of the treatment under study and the observation procedures. Is it really worse to ask an informed patient to volunteer to forgo treatment of mild hypertension for a few weeks than to ask a research subject to undergo a radiologic…",

author = "C. Schechter and S. Gagliano and G. Traversa and Taylor, {H. R.} and Nash, {S. D.} and Gilbert, {E. M.} and M. Packer and Cleophas, {T. J M} and R. Pohl and R. Balon and Denny, {W. F.} and Sramek, {J. J.} and Cutler, {N. R.} and Solomon, {D. A.} and Rothman, {K. J.} and Michels, {K. B.}",

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AU - Schechter, C.

AU - Gagliano, S.

AU - Traversa, G.

AU - Taylor, H. R.

AU - Nash, S. D.

AU - Gilbert, E. M.

AU - Packer, M.

AU - Cleophas, T. J M

AU - Pohl, R.

AU - Balon, R.

AU - Denny, W. F.

AU - Sramek, J. J.

AU - Cutler, N. R.

AU - Solomon, D. A.

AU - Rothman, K. J.

AU - Michels, K. B.

PY - 1995/1/5

Y1 - 1995/1/5

N2 - To the Editor: Rothman and Michels (Aug. 11 issue)1 object to the practice of giving “individual investigators and… institutional review boards the right to determine how much discomfort or temporary disability patients should endure for the purpose of research.” Regardless of what controls are used, precisely such a determination must be made concerning the foreseeable adverse effects of the treatment under study and the observation procedures. Is it really worse to ask an informed patient to volunteer to forgo treatment of mild hypertension for a few weeks than to ask a research subject to undergo a radiologic…

AB - To the Editor: Rothman and Michels (Aug. 11 issue)1 object to the practice of giving “individual investigators and… institutional review boards the right to determine how much discomfort or temporary disability patients should endure for the purpose of research.” Regardless of what controls are used, precisely such a determination must be made concerning the foreseeable adverse effects of the treatment under study and the observation procedures. Is it really worse to ask an informed patient to volunteer to forgo treatment of mild hypertension for a few weeks than to ask a research subject to undergo a radiologic…

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The use of placebo controls

Abstract

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