TY - JOUR
T1 - The use of extracorporeal life support in adolescent amlodipine overdose
AU - Persad, Elizabeth A.
AU - Raman, Lakshmi
AU - Thompson, Marita T.
AU - Sheeran, Paul W.
PY - 2012
Y1 - 2012
N2 - Calcium channel blocker (CCB) toxicity is associated with refractory hypotension and can be fatal. A 13 year old young woman presented to the emergency department(ED) six hours after an intentional overdose of amlodipine, barbiturates, and alcohol. She remained extremely hypotensive despite the administration of normal saline and calcium chloride and despite infusions of norepinephrine, epinephrine, insulin, and dextrose. Due to increasing evidence of end organ dysfunction, Extracorporeal Life Support (ECLS) was initiated 9 hours after presentation to the ED. The patient′s blood pressure and end organ function immediately improved after cannulation. She was successfully decannulated after 57 hours of ECLS and was neurologically intact. Patients with calcium channel blocker overdose who are resistant to medical interventions may respond favorably to early ECLS.
AB - Calcium channel blocker (CCB) toxicity is associated with refractory hypotension and can be fatal. A 13 year old young woman presented to the emergency department(ED) six hours after an intentional overdose of amlodipine, barbiturates, and alcohol. She remained extremely hypotensive despite the administration of normal saline and calcium chloride and despite infusions of norepinephrine, epinephrine, insulin, and dextrose. Due to increasing evidence of end organ dysfunction, Extracorporeal Life Support (ECLS) was initiated 9 hours after presentation to the ED. The patient′s blood pressure and end organ function immediately improved after cannulation. She was successfully decannulated after 57 hours of ECLS and was neurologically intact. Patients with calcium channel blocker overdose who are resistant to medical interventions may respond favorably to early ECLS.
KW - Amlodipine overdose
KW - calcium channel blocker
KW - extra corporeal life support.
UR - http://www.scopus.com/inward/record.url?scp=84875189976&partnerID=8YFLogxK
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U2 - 10.4103/0972-5229.106502
DO - 10.4103/0972-5229.106502
M3 - Article
C2 - 23559727
AN - SCOPUS:84875189976
SN - 0972-5229
VL - 16
SP - 204
EP - 206
JO - Indian Journal of Critical Care Medicine
JF - Indian Journal of Critical Care Medicine
IS - 4
ER -