The use of cytoreductive nephrectomy in patients with renal cell carcinoma

Rashed A. Ghandour, Nirmish Singla, Vitaly Margulis

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations


Introduction: The systemic options for managing metastatic renal cell carcinoma (mRCC) have expanded considerably over the past decade. Initially limited to cytokines, clinicians may now choose from several classes of targeted therapies and, most recently, immune checkpoint inhibitors. Areas covered: In this review, we discuss the role and timing of cytoreductive nephrectomy (CN) and its evolution starting with cytokines, and then alongside the emergence of targeted therapy and novel immunotherapy with immune checkpoint inhibitors. Patient selection remains the most critical determinant in offering CN, and the anticipated survival benefits of CN must be weighed against the surgical morbidity and potential delay to receipt of systemic therapies. Expert opinion: Proper patient selection is key for decision-making in mRCC. Prospective data is urgently needed to define the role of CN in the contemporary immunotherapy era, with greater personalization of prognostic models.

Original languageEnglish (US)
Pages (from-to)405-411
Number of pages7
JournalExpert Review of Anticancer Therapy
Issue number5
StatePublished - May 4 2019


  • Renal cell carcinoma
  • cytoreductive nephrectomy
  • metastatic
  • patient selection
  • targeted therapy

ASJC Scopus subject areas

  • Oncology
  • Pharmacology (medical)


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