TY - JOUR
T1 - The targeting and assembly of peroxisomal proteins
T2 - Some old rules do not apply
AU - McNew, James A.
AU - Goodman, Joel M.
N1 - Funding Information:
Our thanks to A. McDowall and C. Hartfield for helping us with the micrographs shown in Fig. 2, J. Rothblatt for the thiolase antibody, and to members of the Goodman lab for editing this manuscript. The strict limit on references prohibited us from acknowledging many worthy reports. The work was supported by grants from the NIH and The Welch Foundation.
PY - 1996/2
Y1 - 1996/2
N2 - Several proteins have been identified that catalyze the import of proteins into peroxisomes. Some recognize specific peroxisomal targeting sequences, but most probably work further downstream the import pathway. Recent evidence suggests that peroxisomal targeting and assembly do not follow the same rules as those for targeting and import into other organelles, such as the mitochondria and the endoplasmic reticulum, i.e. the import of unfolded proteins and subsequent folding within the organelle. Specifically, proteins may be translocated into the peroxisomal matrix in a folded or oligomerized state.
AB - Several proteins have been identified that catalyze the import of proteins into peroxisomes. Some recognize specific peroxisomal targeting sequences, but most probably work further downstream the import pathway. Recent evidence suggests that peroxisomal targeting and assembly do not follow the same rules as those for targeting and import into other organelles, such as the mitochondria and the endoplasmic reticulum, i.e. the import of unfolded proteins and subsequent folding within the organelle. Specifically, proteins may be translocated into the peroxisomal matrix in a folded or oligomerized state.
UR - http://www.scopus.com/inward/record.url?scp=85047669202&partnerID=8YFLogxK
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U2 - 10.1016/S0968-0004(96)80181-2
DO - 10.1016/S0968-0004(96)80181-2
M3 - Review article
AN - SCOPUS:85047669202
SN - 0968-0004
VL - 21
SP - 54
EP - 58
JO - Trends in biochemical sciences
JF - Trends in biochemical sciences
IS - 2
ER -