The stem cell niche: Theme and variations

Benjamin Ohlstein, Toshie Kai, Eva Decotto, Allan Spradling

Research output: Contribution to journalReview articlepeer-review

293 Scopus citations


Stem cells in animal tissues are often located and controlled by special tissue microenvironments known as niches. Studies of stem cell niches in model systems such as Drosophila have revealed adhesive interactions, cell cycle modifications and intercellular signals that operate to control stem cell behavior. Candidate niches and regulatory molecules have also been identified in many mammalian tissues, including bone marrow, skin, gut and brain. While niches are an ancient evolutionary device with conserved features across diverse organisms, we suggest that certain niches display important differences in their organization and function.

Original languageEnglish (US)
Pages (from-to)693-699
Number of pages7
JournalCurrent Opinion in Cell Biology
Issue number6
StatePublished - Dec 2004
Externally publishedYes

ASJC Scopus subject areas

  • Cell Biology


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