Abstract
Proline, glutamic acid- and leucine-rich protein 1 (PELP1) is a multi-domain scaffold protein that serves as a platform for various protein-protein interactions between steroid receptors (SRs) and signaling factors and cell cycle, transcriptional, cytoskeletal, and epigenetic remodelers. PELP1 is known to be a coregulator of transcription and participates in the nuclear and extranuclear functions of SRs, ribosome biogenesis, and cell cycle progression. The expression and localization of PELP1 are dysregulated in hormonal cancers including breast and prostate cancers. This review focuses on the interactive functions and therapeutic and prognostic significance of PELP1 in breast and prostate cancers.
Original language | English (US) |
---|---|
Pages (from-to) | T79-T86 |
Journal | Endocrine-Related Cancer |
Volume | 21 |
Issue number | 4 |
DOIs | |
State | Published - Aug 2014 |
Keywords
- Coregulator
- Epigenetics
- Genomic signaling
- Hormonal cancers
- Interactome
- Network
- Nongenomic signaling
- PELP1
- Steroid receptors
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism
- Oncology
- Endocrinology
- Cancer Research