The septin family of GTPases: Architecture and dynamics

Research output: Contribution to journalReview articlepeer-review

260 Scopus citations


Septins comprise a conserved family of proteins that are found primarily in fungi and animals. These GTP-binding proteins have several roles during cell division, cytoskeletal organization and membrane-remodelling events. One factor that is crucial for their functions is the ordered assembly of individual septins into oligomeric core complexes that, in turn, form higher-order structures such as filaments, rings and gauzes. The molecular details of these interactions and the mechanism by which septin-complex assembly is regulated have remained elusive. Recently, the first detailed structural views of the septin core have emerged, and these, along with studies of septin dynamics in vivo, have provided new insight into septin-complex assembly and septin function in vivo.

Original languageEnglish (US)
Pages (from-to)478-489
Number of pages12
JournalNature Reviews Molecular Cell Biology
Issue number6
StatePublished - Jun 10 2008

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology


Dive into the research topics of 'The septin family of GTPases: Architecture and dynamics'. Together they form a unique fingerprint.

Cite this