TY - JOUR
T1 - The role of the transcription factor ets1 in lupus and other autoimmune diseases
AU - Garrett-Sinha, Lee Ann
AU - Kearly, Alyssa
AU - Satterthwaite, Anne B.
N1 - Publisher Copyright:
© 2016 by Begell House, Inc.
PY - 2016
Y1 - 2016
N2 - Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by excess B- and T-cell activation, the development of autoantibodies against self-antigens including nuclear antigens, and immune complex deposition in target organs, which triggers an inflammatory response and tissue damage. The genetic and environmental factors that contribute to the development of SLE have been studied extensively in both humans and mouse models of the disease. One of the important genetic contributions to SLE development is an alteration in the expression of the transcription factor Ets1, which regulates the functional differentiation of lymphocytes. Here, we review the genetic, biochemical, and immunological studies that have linked low levels of Ets1 to aberrant lymphocyte differentiation and to the pathogenesis of SLE.
AB - Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by excess B- and T-cell activation, the development of autoantibodies against self-antigens including nuclear antigens, and immune complex deposition in target organs, which triggers an inflammatory response and tissue damage. The genetic and environmental factors that contribute to the development of SLE have been studied extensively in both humans and mouse models of the disease. One of the important genetic contributions to SLE development is an alteration in the expression of the transcription factor Ets1, which regulates the functional differentiation of lymphocytes. Here, we review the genetic, biochemical, and immunological studies that have linked low levels of Ets1 to aberrant lymphocyte differentiation and to the pathogenesis of SLE.
KW - Autoantibodies
KW - B-cell tolerance
KW - Ets1
KW - Plasma cells
KW - Systemic lupus erythematosus
KW - T-cell cytokines
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U2 - 10.1615/CritRevImmunol.2017020284
DO - 10.1615/CritRevImmunol.2017020284
M3 - Review article
C2 - 28845756
AN - SCOPUS:85035322763
SN - 1040-8401
VL - 36
SP - 485
EP - 509
JO - Critical Reviews in Immunology
JF - Critical Reviews in Immunology
IS - 6
ER -