TY - JOUR
T1 - The role of the actin cytoskeleton in regulating Drosophila behavior
AU - Ojelade, Shamsideen A.
AU - Acevedo, Summer F.
AU - Rothenfluh, Adrian
N1 - Funding Information:
Adrian Rothenfluh received his Diploma in molecular biology from the Biocenter, University of Basel, Switzerland, and his PhD in genetics from Rockefeller University in New York. Following postdoctoral training at UCSF, he became an assistant professor in the Department of Psychiatry at UT Southwestern Medical Center in Dallas, TX in 2007. He is funded by the NIH (R01AA019526), the Brain & Behavior Research Foundation, and the Endowed Scholars Program at UTSW.
Funding Information:
Acknowledgments: Shamsideen A. Ojelade has received funding from the NIH through a NIDA institutional grant (T32 DA7290) and currently is completing his thesis dissertation under a F31-NIAAA fellowship (F31 AA021340). Adrian Rothenfluh’s work is funded by the NIH (R01AA019526), the Brain & Behavior Research Foundation, and the Endowed Scholars Program at UTSW.
PY - 2013/10
Y1 - 2013/10
N2 - Over the past decade, the function of the cytoskeleton has been studied extensively in developing and mature neurons. Actin, a major cytoskeletal protein, is indispensable for the structural integrity and plasticity of neurons and their synapses. Disruption of actin dynamics has significant consequence for neurons, neuronal circuits, and the functions they govern. In particular, cell adhesion molecules, members of the Rho family of GTPases, and actin-binding proteins are important modulators of actin dynamics and neuronal as well as behavioral plasticity. In this review, we discuss recent advances in Drosophila that highlight the importance of actin regulatory proteins in mediating fly behaviors such as circadian rhythm, courtship behavior, learning and memory, and the development of drug addiction.
AB - Over the past decade, the function of the cytoskeleton has been studied extensively in developing and mature neurons. Actin, a major cytoskeletal protein, is indispensable for the structural integrity and plasticity of neurons and their synapses. Disruption of actin dynamics has significant consequence for neurons, neuronal circuits, and the functions they govern. In particular, cell adhesion molecules, members of the Rho family of GTPases, and actin-binding proteins are important modulators of actin dynamics and neuronal as well as behavioral plasticity. In this review, we discuss recent advances in Drosophila that highlight the importance of actin regulatory proteins in mediating fly behaviors such as circadian rhythm, courtship behavior, learning and memory, and the development of drug addiction.
KW - Actin
KW - Behavior
KW - Drosophila
KW - Genetics
UR - http://www.scopus.com/inward/record.url?scp=84888144863&partnerID=8YFLogxK
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U2 - 10.1515/revneuro-2013-0017
DO - 10.1515/revneuro-2013-0017
M3 - Article
C2 - 24077615
AN - SCOPUS:84888144863
SN - 0334-1763
VL - 24
SP - 471
EP - 484
JO - Reviews in the Neurosciences
JF - Reviews in the Neurosciences
IS - 5
ER -