The role of PTHrP in vascular smooth muscle

Dwight A. Towler

doi:10.1007/s12018-014-9169-2

The role of PTHrP in vascular smooth muscle

Dwight A. Towler

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

All calciotropic hormones have vasculotropic actions. This terse tenet challenges us to re-think the roles played by the PTH/PTHrP receptor (PTH1R) in vertebrate physiology. PTH1R signaling does not only control bone formation and serum calcium phosphate homeostasis. Cues dependent upon the PTH1R maintain myocardial viability during prenatal development and regulate arteriosclerotic calcification and vascular remodeling during post-natal life. A better understanding of the mechanisms whereby PTH/PTHrP signaling impacts the cardiovascular system will provide therapeutic insights useful for treating patients afflicted with heart failure, chronic kidney disease-mineral and bone disorder, and diabetic arteriosclerosis.

Original language	English (US)
Pages (from-to)	190-196
Number of pages	7
Journal	Clinical Reviews in Bone and Mineral Metabolism
Volume	12
Issue number	3
DOIs	https://doi.org/10.1007/s12018-014-9169-2
State	Published - Sep 2014

Keywords

Arteriosclerosis
Cardiovascular endocrinology
Intracrine signaling
P27Kip1
Paracrine signaling
Parathyroid hormone-related polypeptide

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Orthopedics and Sports Medicine
Endocrinology

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10.1007/s12018-014-9169-2

Cite this

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abstract = "All calciotropic hormones have vasculotropic actions. This terse tenet challenges us to re-think the roles played by the PTH/PTHrP receptor (PTH1R) in vertebrate physiology. PTH1R signaling does not only control bone formation and serum calcium phosphate homeostasis. Cues dependent upon the PTH1R maintain myocardial viability during prenatal development and regulate arteriosclerotic calcification and vascular remodeling during post-natal life. A better understanding of the mechanisms whereby PTH/PTHrP signaling impacts the cardiovascular system will provide therapeutic insights useful for treating patients afflicted with heart failure, chronic kidney disease-mineral and bone disorder, and diabetic arteriosclerosis.",

keywords = "Arteriosclerosis, Cardiovascular endocrinology, Intracrine signaling, P27Kip1, Paracrine signaling, Parathyroid hormone-related polypeptide",

author = "Towler, {Dwight A.}",

note = "Funding Information: Acknowledgments D.A.T. is supported by Grants HL069229, HL081138, and HL114806 from the National Institutes of Health, the Sanford-Burnham Medical Research Institute, and the Florida Hospital Translational Research Institute.",

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N2 - All calciotropic hormones have vasculotropic actions. This terse tenet challenges us to re-think the roles played by the PTH/PTHrP receptor (PTH1R) in vertebrate physiology. PTH1R signaling does not only control bone formation and serum calcium phosphate homeostasis. Cues dependent upon the PTH1R maintain myocardial viability during prenatal development and regulate arteriosclerotic calcification and vascular remodeling during post-natal life. A better understanding of the mechanisms whereby PTH/PTHrP signaling impacts the cardiovascular system will provide therapeutic insights useful for treating patients afflicted with heart failure, chronic kidney disease-mineral and bone disorder, and diabetic arteriosclerosis.

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KW - Cardiovascular endocrinology

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The role of PTHrP in vascular smooth muscle

Abstract

Keywords

ASJC Scopus subject areas

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