The role of prostaglandins in NSAID induced renal dysfunction

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6 Scopus citations


Renal prostaglandins (PG) play an important role in regulating renal hemodynamics and excretory function in 2 conditions (1) which effective arterial blood volume is reduced and (2) chronic renal failure is reduced. The use of nonsteroidal antiinflammatory drugs (NSAID) in patients with these conditions can produce a significant decline in renal function, including decreased glomerular filtration rate and solute and water excretion, by inhibiting renal cyclooxygenase, and thus, PG production. Results of preliminary investigation with the PGE1 analog misoprostol suggest that exogenous PG analogs may be effective in counteracting the effects of NSAID in such settings. Further clinical studies will be needed to establish the role of PG in this setting.

Original languageEnglish (US)
Pages (from-to)22-25
Number of pages4
JournalJournal of Rheumatology
Issue numberSUPPL. 28
StatePublished - Jan 1 1991


  • Hemodynamic acute renal failure
  • Mistoprostol
  • NSAID induced renal dysfunction
  • Prostaglandin analogs
  • Prostaglandins

ASJC Scopus subject areas

  • Rheumatology
  • Immunology and Allergy
  • Immunology


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