The Role of NF-κB in Central Tolerance

Mingzhao Zhu, Matthew Ruddy, Yang Xin Fu

Research output: Chapter in Book/Report/Conference proceedingChapter


The nuclear factor kB (NF-kB) transcription factor family plays a critical role in regulating the immune system. Aberrant NF-kB signalling is frequently associated with inflammation and autoimmune diseases but the mechanisms are unclear. Two NF-kB signalling pathways have been identified: the canonical pathway and the alternative pathway. However, these two signalling pathways do not exist in isolation and cross-regulation commonly occurs. Both pathways play important roles in establishing central tolerance. The alternative pathway appears to be the key signalling component in stromal cells, while the canonical pathway exerts its function more in autonomous T cells. Increased signalling of the canonical pathway is often associated with increased T cell activation, and inflammation and recent studies show that lack of signalling of the alternative pathway could also lead to increased inflammation by impairing central tolerance.

Original languageEnglish (US)
Title of host publicationThe Epigenetics of Autoimmune Diseases
PublisherJohn Wiley and Sons
Number of pages16
ISBN (Print)9780470758618
StatePublished - Apr 29 2009


  • NF-κB pathway, influencing Treg development
  • Nuclear factor κB (NF-κB)
  • Receptor activator of NF-κB ligand (RANKL)
  • Rel homology domain (RHD)
  • Role of NF-κB in central tolerance
  • Tumour necrosis factor α (TNF-α) and interleukin (IL)-1, inducing NF-κB pathway
  • Twist and PIAS1, inhibiting RelA transactivation activity
  • Ubiquitination in activation of NF-κB pathways

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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