TY - JOUR
T1 - The role of modulatory calcineurin-interacting proteins in calcineurin signaling
AU - Rothermel, Beverly A.
AU - Vega, Rick B.
AU - Williams, R. Sanders
N1 - Funding Information:
The authors would like to thank Drs. Rhonda Bassel-Duby, Shane Kanatous, Annette Meeson, and Eric N. Olson for invaluable discussions and critical comments. They would also like to acknowledge grant support from the National Institutes of Health (AR40849), the Donald W. Reynolds Foundation, and the American Heart Association Texas Affiliate (0160099Y).
PY - 2003/1
Y1 - 2003/1
N2 - Modulatory calcineurin-interacting proteins (MCIPs), also known as the Down syndrome critical region 1 (DSCR1) and DSCR1-like proteins, are a recently described family of small, structurally related proteins that are preferentially expressed in heart, skeletal muscle, and brain. MCIP proteins can bind to and inhibit calcineurin, a calcium/calmodulin-regulated serine/threonine protein phosphatase that is activated during cardiac hypertrophy and failure. Transcription of the mammalian MCIP1 gene is induced by calcineurin, suggesting that it functions as an endogenous feedback regulator of calcineurin signal transduction. Forced expression of human MCIP1 protein in the hearts of transgenic mice attenuates the hypertrophic response to a broad range of stimuli. This review summarizes work from a number of laboratories on the structure, regulation, and function of MCIP proteins.
AB - Modulatory calcineurin-interacting proteins (MCIPs), also known as the Down syndrome critical region 1 (DSCR1) and DSCR1-like proteins, are a recently described family of small, structurally related proteins that are preferentially expressed in heart, skeletal muscle, and brain. MCIP proteins can bind to and inhibit calcineurin, a calcium/calmodulin-regulated serine/threonine protein phosphatase that is activated during cardiac hypertrophy and failure. Transcription of the mammalian MCIP1 gene is induced by calcineurin, suggesting that it functions as an endogenous feedback regulator of calcineurin signal transduction. Forced expression of human MCIP1 protein in the hearts of transgenic mice attenuates the hypertrophic response to a broad range of stimuli. This review summarizes work from a number of laboratories on the structure, regulation, and function of MCIP proteins.
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U2 - 10.1016/S1050-1738(02)00188-3
DO - 10.1016/S1050-1738(02)00188-3
M3 - Review article
C2 - 12554096
AN - SCOPUS:0037237668
SN - 1050-1738
VL - 13
SP - 15
EP - 21
JO - Trends in Cardiovascular Medicine
JF - Trends in Cardiovascular Medicine
IS - 1
ER -