TY - JOUR
T1 - The role of metabolic states in development and disease
AU - Sieber, Matthew H.
AU - Spradling, Allan C.
N1 - Funding Information:
We apologize to authors whose work could not be cited due to space limitations. Allan Spradling is supported by HHMI and the Carnegie Institution for Science and Matthew Sieber is funded by the Jane Coffin Childs Research Fund.
Publisher Copyright:
© 2017 Elsevier Ltd
PY - 2017/8/1
Y1 - 2017/8/1
N2 - During development, cells adopt distinct metabolic strategies to support growth, produce energy, and meet the demands of a mature tissue. Some of these metabolic states maintain a constrained program of nutrient utilization, while others providing metabolic flexibility as a means to couple developmental progression with nutrient availability. Here we discuss our understanding of metabolic programs, and how they support specific aspects of animal development. During phases of rapid proliferation a subset of metabolic programs provide the building blocks to support growth. During differentiation, metabolic programs shift to support the unique demands of each tissue. Finally, we discuss how a model system, such as Drosophila egg development, can provide a versatile platform to discover novel mechanisms controlling programmed shift in metabolism.
AB - During development, cells adopt distinct metabolic strategies to support growth, produce energy, and meet the demands of a mature tissue. Some of these metabolic states maintain a constrained program of nutrient utilization, while others providing metabolic flexibility as a means to couple developmental progression with nutrient availability. Here we discuss our understanding of metabolic programs, and how they support specific aspects of animal development. During phases of rapid proliferation a subset of metabolic programs provide the building blocks to support growth. During differentiation, metabolic programs shift to support the unique demands of each tissue. Finally, we discuss how a model system, such as Drosophila egg development, can provide a versatile platform to discover novel mechanisms controlling programmed shift in metabolism.
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U2 - 10.1016/j.gde.2017.03.002
DO - 10.1016/j.gde.2017.03.002
M3 - Review article
C2 - 28347941
AN - SCOPUS:85016070340
SN - 0959-437X
VL - 45
SP - 58
EP - 68
JO - Current Opinion in Genetics and Development
JF - Current Opinion in Genetics and Development
ER -