Abstract
The results of recent in vitro investigations have suggested a major role of LDL-cholesterol as a factor regulating P biosynthesis by the human CL. The vascularization of the CL allows for a mechanism whereby LDL-cholesterol gains access to the luteinized granulosa cells. The levels of LDL in follicular fluid and in plasma during the luteal phase of normal women support the significance of LDL in the regulation of P in vivo. Finally, the low levels of P and the absence of LDL in plasma in women with abetalipoproteinemia and in the observations of women with poor vascularization of the CL suggest that deficiencies in delivery of LDL to the luteinized granulosa cells during the luteal phase may result in luteal phase dysfunction.
Original language | English (US) |
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Pages (from-to) | 303-311 |
Number of pages | 9 |
Journal | Fertility and sterility |
Volume | 38 |
Issue number | 3 |
DOIs | |
State | Published - 1982 |
ASJC Scopus subject areas
- Reproductive Medicine
- Obstetrics and Gynecology