The role of lipid signaling in constitutive membrane traffic

Michael G. Roth, Paul C. Sternweis

Research output: Contribution to journalArticlepeer-review

92 Scopus citations


Several lines of evidence indicate that enzymes that modify membrane lipids function in the regulation of constitutive membrane traffic. Recent evidence suggests that specific phosphatidylinositides may regulate the activity of proteins with diverse functions in membrane transport, such as dynamin, the clathrin-associated AP-2 complex, and proteins that stimulate guanine nucleotide exchange on ADP-ribosylation factors (ARFs). ARF proteins activate a phospholipase D that produces phosphatidic acid from phosphatidylcholine, and this may be essential for the formation of certain types of transport vesicles or may tie constitutive vesicular transport to signal transduction pathways.

Original languageEnglish (US)
Pages (from-to)519-526
Number of pages8
JournalCurrent Opinion in Cell Biology
Issue number4
StatePublished - Aug 1997

ASJC Scopus subject areas

  • Cell Biology


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