Abstract
Hair follicles (HFs) strongly interact with adipocytes within the dermal white adipose tissue (dWAT), suggesting a strong physiological dependence on the content of immature and mature adipocytes in this layer. This content is regulated by the proliferation and differentiation of adipocyte precursors, as well as by dedifferentiation of mature existing adipocytes. Spatially, long-range interactions between HFs and dWAT involve the exchange of extracellular vesicles which are differentially released by precursors, preadipocytes, and mature adipocytes. Different exogenous factors, including light irradiation, are likely to modify the release of adipocyte-derived exosomes in dWAT, which can lead to aberrations of the HF cycle. Consequently, dWAT should be considered as a potential target for the modulation of hair growth.
Original language | English (US) |
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Pages (from-to) | 93-105 |
Number of pages | 13 |
Journal | Trends in Endocrinology and Metabolism |
Volume | 30 |
Issue number | 2 |
DOIs | |
State | Published - Feb 2019 |
Keywords
- dermal white adipose tissue
- exosomal exchange
- hair follicle cycle
- immature adipocytes
- mature adipocytes
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism
- Endocrinology