The Role of Immature and Mature Adipocytes in Hair Cycling

Ilja L. Kruglikov, Zhuzhen Zhang, Philipp E Scherer

Research output: Contribution to journalReview articlepeer-review

23 Scopus citations


Hair follicles (HFs) strongly interact with adipocytes within the dermal white adipose tissue (dWAT), suggesting a strong physiological dependence on the content of immature and mature adipocytes in this layer. This content is regulated by the proliferation and differentiation of adipocyte precursors, as well as by dedifferentiation of mature existing adipocytes. Spatially, long-range interactions between HFs and dWAT involve the exchange of extracellular vesicles which are differentially released by precursors, preadipocytes, and mature adipocytes. Different exogenous factors, including light irradiation, are likely to modify the release of adipocyte-derived exosomes in dWAT, which can lead to aberrations of the HF cycle. Consequently, dWAT should be considered as a potential target for the modulation of hair growth.

Original languageEnglish (US)
Pages (from-to)93-105
Number of pages13
JournalTrends in Endocrinology and Metabolism
Issue number2
StatePublished - Feb 2019


  • dermal white adipose tissue
  • exosomal exchange
  • hair follicle cycle
  • immature adipocytes
  • mature adipocytes

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology


Dive into the research topics of 'The Role of Immature and Mature Adipocytes in Hair Cycling'. Together they form a unique fingerprint.

Cite this