The role of estrogens in the adipose tissue milieu

John R. Bracht, Victoria J. Vieira-Potter, Roberta De Souza Santos, Orhan K. Öz, Biff F. Palmer, Deborah J. Clegg

Research output: Contribution to journalReview articlepeer-review

28 Scopus citations


One of the leading causes for the development of adverse metabolic effects, including type 2 diabetes, dyslipidemia, and cardiovascular diseases, is the accumulation of excess body weight, often measured by body mass index (BMI). Although BMI, calculated using weight and height, is the standard measure used to determine body adiposity in clinical and public health guidelines, an inherent limitation is that BMI does not distinguish where in the body adiposity is deposited. Central obesity, characterized by greater accumulation of adiposity in the abdominal region, has been associated with a higher risk of mortality, independent of BMI. Importantly, one of the determinants of body fat distribution is sex hormones. Both estrogens and androgens appear to directly and indirectly influence body fat distribution. Our review will focus specifically on the role of estrogens and their influence in determining body fat distribution and overall health of adipose tissues, and the role of epigenetic mechanisms in regulating the production and function of estrogens.

Original languageEnglish (US)
Pages (from-to)127-143
Number of pages17
JournalAnnals of the New York Academy of Sciences
Issue number1
StatePublished - 2020


  • adipose tissue
  • estrogens
  • obesity

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science


Dive into the research topics of 'The role of estrogens in the adipose tissue milieu'. Together they form a unique fingerprint.

Cite this