TY - JOUR
T1 - The role of epigenetic mechanisms in the regulation of gene expression in the nervous system
AU - Cholewa-Waclaw, Justyna
AU - Bird, Adrian
AU - von Schimmelmann, Melanie
AU - Schaefer, Anne
AU - Yu, Huimei
AU - Song, Hongjun
AU - Madabhushi, Ram
AU - Tsai, Li Huei
N1 - Publisher Copyright:
© 2016 the authors.
PY - 2016/11/9
Y1 - 2016/11/9
N2 - Neuroepigenetics is a newly emerging field in neurobiology that addresses the epigenetic mechanism of gene expression regulation in various postmitotic neurons, both over time and in response to environmental stimuli. In addition to its fundamental contribution to our understanding of basic neuronal physiology, alterations in these neuroepigenetic mechanisms have been recently linked to numerous neurodevelopmental, psychiatric, and neurodegenerative disorders. This article provides a selective review of the role of DNA and histone modifications in neuronal signal-induced gene expression regulation, plasticity, and survival and how targeting these mechanisms could advance the development of future therapies. In addition, we discuss a recent discovery on how double-strand breaks of genomic DNA mediate the rapid induction of activity-dependent gene expression in neurons.
AB - Neuroepigenetics is a newly emerging field in neurobiology that addresses the epigenetic mechanism of gene expression regulation in various postmitotic neurons, both over time and in response to environmental stimuli. In addition to its fundamental contribution to our understanding of basic neuronal physiology, alterations in these neuroepigenetic mechanisms have been recently linked to numerous neurodevelopmental, psychiatric, and neurodegenerative disorders. This article provides a selective review of the role of DNA and histone modifications in neuronal signal-induced gene expression regulation, plasticity, and survival and how targeting these mechanisms could advance the development of future therapies. In addition, we discuss a recent discovery on how double-strand breaks of genomic DNA mediate the rapid induction of activity-dependent gene expression in neurons.
KW - DNA double strand breaks
KW - DNA methylation
KW - MeCP2
KW - Polycomb repressive complex
KW - Topoisomerase II
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U2 - 10.1523/JNEUROSCI.2492-16.2016
DO - 10.1523/JNEUROSCI.2492-16.2016
M3 - Article
C2 - 27911745
AN - SCOPUS:84994713348
SN - 0270-6474
VL - 36
SP - 11427
EP - 11434
JO - Journal of Neuroscience
JF - Journal of Neuroscience
IS - 45
ER -