TY - JOUR
T1 - The role of cachectin/TNF in endotoxic shock and cachexia
AU - Ceramil, Anthony
AU - Beutler, Bruce
PY - 1988
Y1 - 1988
N2 - The histories of tumor necrosis factor (TNF) and cachectin have recently converged, with the recognition that they are one and the same molecule. Cachectin/TNF appears to be a major factor in the pathology that accompanies invasion by a foreign organism - the host mounts an exagerated response that is itself debilatory. Here, Bruce Beutler and Anthony Cerami review the involvement of cachectin/TNF in wasting and shock, as well as its more beneficial influences.
AB - The histories of tumor necrosis factor (TNF) and cachectin have recently converged, with the recognition that they are one and the same molecule. Cachectin/TNF appears to be a major factor in the pathology that accompanies invasion by a foreign organism - the host mounts an exagerated response that is itself debilatory. Here, Bruce Beutler and Anthony Cerami review the involvement of cachectin/TNF in wasting and shock, as well as its more beneficial influences.
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UR - http://www.scopus.com/inward/citedby.url?scp=0023671596&partnerID=8YFLogxK
U2 - 10.1016/0167-5699(88)91353-9
DO - 10.1016/0167-5699(88)91353-9
M3 - Review article
C2 - 3076757
AN - SCOPUS:0023671596
SN - 1471-4906
VL - 9
SP - 28
EP - 31
JO - Trends in Immunology
JF - Trends in Immunology
IS - 1
ER -