TY - JOUR
T1 - The role of Bruton's tyrosine kinase in B-cell development and function
T2 - A genetic perspective
AU - Satterthwaite, Anne B.
AU - Witte, Owen N.
PY - 2000
Y1 - 2000
N2 - Mutations in Bruton's tyrosine kinase (Btk) result in the B-cell immunodeficiencies X-linked agammaglobulinemia in humans and X-linked immunodeficiency in mice. These diseases are characterized by blocks in B-cell development at multiple stages and impaired function of residual mature B cells. This review focuses on a series of in vivo genetic studies that have begun to define the mechanism by which Btk regulates B-cell development and function. The functional interactions between Btk and other signaling molecules defined by this approach are more complex than initially appreciated from in vitro biochemical and cell culture studies.
AB - Mutations in Bruton's tyrosine kinase (Btk) result in the B-cell immunodeficiencies X-linked agammaglobulinemia in humans and X-linked immunodeficiency in mice. These diseases are characterized by blocks in B-cell development at multiple stages and impaired function of residual mature B cells. This review focuses on a series of in vivo genetic studies that have begun to define the mechanism by which Btk regulates B-cell development and function. The functional interactions between Btk and other signaling molecules defined by this approach are more complex than initially appreciated from in vitro biochemical and cell culture studies.
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U2 - 10.1034/j.1600-065X.2000.017504.x
DO - 10.1034/j.1600-065X.2000.017504.x
M3 - Article
C2 - 10933597
AN - SCOPUS:0033945186
SN - 0105-2896
VL - 175
SP - 120
EP - 127
JO - Immunological Reviews
JF - Immunological Reviews
ER -