TY - JOUR
T1 - The Role of Bile Acids in the Overall Regulation of Steroid Metabolism
AU - Wilson, J. D.
N1 - Funding Information:
Supported in part by grants from the Public HealthService(AM08749)andfromtheAmeri¬ canHeartAssociation.
PY - 1972/10
Y1 - 1972/10
N2 - Bile acids, themselves end products of cholesterol catabolism, act to regulate virtually every step in cholesterol metabolism, including dietary absorption, endogenous synthesis, excretion, and bile acid formation. Although many aspects of the interaction between bile acids and cholesterol are poorly understood, in regard to bile acid synthesis the effect of bile acids is homeostatic. On the one hand, bile acid formation increases following bile acid deprivation in order to provide adequate bile acids to maintain fat absorption, whereas bile acid excess in the diet or circulation is compensated by diminished bile acid synthesis. Furthermore, the net effect of bile acid on cholesterol metabolism is to maintain a balance in which synthesis and absorption tend to equal excretion and degradation under diverse physiological conditions and, thus, to minimize either cholesterol accrual or cholesterol deficiency.
AB - Bile acids, themselves end products of cholesterol catabolism, act to regulate virtually every step in cholesterol metabolism, including dietary absorption, endogenous synthesis, excretion, and bile acid formation. Although many aspects of the interaction between bile acids and cholesterol are poorly understood, in regard to bile acid synthesis the effect of bile acids is homeostatic. On the one hand, bile acid formation increases following bile acid deprivation in order to provide adequate bile acids to maintain fat absorption, whereas bile acid excess in the diet or circulation is compensated by diminished bile acid synthesis. Furthermore, the net effect of bile acid on cholesterol metabolism is to maintain a balance in which synthesis and absorption tend to equal excretion and degradation under diverse physiological conditions and, thus, to minimize either cholesterol accrual or cholesterol deficiency.
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U2 - 10.1001/archinte.1972.03650040027004
DO - 10.1001/archinte.1972.03650040027004
M3 - Article
C2 - 4562148
AN - SCOPUS:0015419756
SN - 0003-9926
VL - 130
SP - 493
EP - 505
JO - Archives of Internal Medicine
JF - Archives of Internal Medicine
IS - 4
ER -