The relationship between obsessive-compulsive symptoms and PARKIN genotype: The CORE-PD study

Madeleine E. Sharp, Elise Caccappolo, Helen Mejia-Santana, Ming X. Tang, Llency Rosado, Martha Orbe Reilly, Diana Ruiz, Elan D. Louis, Cynthia Comella, Martha Nance, Susan Bressman, William K. Scott, Caroline Tanner, Cheryl Waters, Stanley Fahn, Lucien Cote, Blair Ford, Michael Rezak, Kevin Novak, Joseph H. FriedmanRonald Pfeiffer, Haydeh Payami, Eric Molho, Stuart A. Factor, John Nutt, Carmen Serrano, Maritza Arroyo, Michael W. Pauciulo, William C. Nichols, Lorraine N. Clark, Roy N. Alcalay, Karen S. Marder

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


Background: Few studies have systematically investigated the association between PARKIN genotype and psychiatric co-morbidities of Parkison's disease (PD). PARKIN-associated PD is characterized by severe nigral dopaminergic neuronal loss, a finding that may have implications for behaviors rooted in dopaminergic circuits such as obsessive-compulsive symptoms (OCS). Methods: The Schedule of Compulsions and Obsessions Patient Inventory (SCOPI) was administered to 104 patients with early-onset PD and 257 asymptomatic first-degree relatives. Carriers of one and two PARKIN mutations were compared with noncarriers. Results: Among patients, carriers scored lower than noncarriers in adjusted models (one-mutation: 13.9 point difference, P=0.03; two-mutation: 24.1, P=0.001), where lower scores indicate less OCS. Among asymptomatic relatives, a trend toward the opposite was seen: mutation carriers scored higher than noncarriers (one mutation, P=0.05; two mutations, P=0.13). Conclusions: First, a significant association was found between PARKIN mutation status and obsessive-compulsive symptom level in both PD and asymptomatic patients, suggesting that OCS might represent an early non-motor dopamine-dependent feature. Second, irrespective of disease status, heterozygotes were significantly different from noncarriers, suggesting that PARKIN heterozygosity may contribute to phenotype.

Original languageEnglish (US)
Pages (from-to)278-283
Number of pages6
JournalMovement Disorders
Issue number2
StatePublished - Feb 1 2015
Externally publishedYes


  • Neuropsychological
  • Obsessive-compulsive
  • Parkin
  • Parkinson's

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


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