Abstract
Background: Abnormal invasive hemodynamics after transcatheter aortic valve replacement (TAVR) is associated with poor survival; however, the mechanism is unknown. Hypothesis: Diastolic dysfunction will modify the association between invasive hemodynamics postTAVR and mortality. Methods: Patients with echocardiographic assessment of diastolic function and postTAVR invasive hemodynamic assessment were eligible for the present analysis. Diastology was classified as normal or abnormal (Stages 1 to 3). The aorto-ventricular index (AVi) was calculated as the difference between the aortic diastolic and the left ventricular end-diastolic pressure divided by the heart rate. AVi was categorized as abnormal (AVi < 0.5 mmHg/beats per minute) or normal (≥ 0.5 mmHg/beats per minute). Results: From 1339 TAVR patients, 390 were included in the final analysis. The mean follow-up was 3.3 ± 1.7 years. Diastolic dysfunction was present in 70.9% of the abnormal vs 55.1% of the normal AVi group (P <.001). All-cause mortality was 46% in the abnormal vs 31% in the normal AVi group (P <.001). Adjusted hazard ratio (HR) for AVi < 0.5 mmHg/beats per minute vs AVi ≥0.5 mmHg/beats per minute for intermediate-term mortality was (HR = 1.5, 95% confidence interval [CI] 1.1 to 2.1, P =.017). This association was the same among those with normal diastolic function and those with diastolic dysfunction (P for interaction =.35). Conclusion: Diastolic dysfunction is prevalent among TAVR patients. Low AVi is an independent predictor for poor intermediate-term survival, irrespective of co-morbid diastolic dysfunction.
Original language | English (US) |
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Pages (from-to) | 1428-1434 |
Number of pages | 7 |
Journal | Clinical Cardiology |
Volume | 43 |
Issue number | 12 |
DOIs | |
State | Published - Dec 2020 |
Keywords
- aortic stenosis
- aorto-ventricular index
- diastolic dysfunction
- filling pressures
- invasive hemodynamics
- prognosis
- transcatheter aortic valve replacement
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine