REGULATION DE L'ACTIVATION DES CELLULES CYTOTOXIQUES PAR L'INTERMEDIAIRE DES LYMPHOKINES

M. Uotila; H. N. Rode; J. Gordon

REGULATION DE L'ACTIVATION DES CELLULES CYTOTOXIQUES PAR L'INTERMEDIAIRE DES LYMPHOKINES

Translated title of the contribution: The regulation of the activation of cytotoxic lymphocytes may be mediated by a lymphokine

M. Uotila, H. N. Rode, J. Gordon

Neurology & Neurotherapeutics

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

MLC CML reactivity declines after approximately the 7th day of culture. The experiments described were designed to probe the reason for this decline, envisaged as due to the lack of one of the signals (HLA A,B or HLA D determinants) required for CML activation. Either fresh stimulating cells or a lymphokine blastogenic factor (BF) were added daily to mixed cultures from the 5th to the 12th day of incubation. Whereas stimulating cells were without effect, added BF maintained both proliferative and cytotoxic activity of the cells in culture. These observations, together with previous results, were interpreted to suggest that helper cells may regulate the activation of cytotoxic lymphocytes by means of soluble mediators.

Translated title of the contribution	The regulation of the activation of cytotoxic lymphocytes may be mediated by a lymphokine
Original language	French
Title of host publication	COLLECT.ANN.INST.PASTEUR
Pages	65-66
Number of pages	2
Volume	128 C
Edition	1-2
State	Published - 1977

ASJC Scopus subject areas

General Medicine

Cite this

@inbook{febedd6c3a2f439aae99ece1ec58514b,

title = "REGULATION DE L'ACTIVATION DES CELLULES CYTOTOXIQUES PAR L'INTERMEDIAIRE DES LYMPHOKINES",

abstract = "MLC CML reactivity declines after approximately the 7th day of culture. The experiments described were designed to probe the reason for this decline, envisaged as due to the lack of one of the signals (HLA A,B or HLA D determinants) required for CML activation. Either fresh stimulating cells or a lymphokine blastogenic factor (BF) were added daily to mixed cultures from the 5th to the 12th day of incubation. Whereas stimulating cells were without effect, added BF maintained both proliferative and cytotoxic activity of the cells in culture. These observations, together with previous results, were interpreted to suggest that helper cells may regulate the activation of cytotoxic lymphocytes by means of soluble mediators.",

author = "M. Uotila and Rode, {H. N.} and J. Gordon",

year = "1977",

language = "French",

volume = "128 C",

pages = "65--66",

booktitle = "COLLECT.ANN.INST.PASTEUR",

edition = "1-2",

}

TY - CHAP

T1 - REGULATION DE L'ACTIVATION DES CELLULES CYTOTOXIQUES PAR L'INTERMEDIAIRE DES LYMPHOKINES

AU - Uotila, M.

AU - Rode, H. N.

AU - Gordon, J.

PY - 1977

Y1 - 1977

N2 - MLC CML reactivity declines after approximately the 7th day of culture. The experiments described were designed to probe the reason for this decline, envisaged as due to the lack of one of the signals (HLA A,B or HLA D determinants) required for CML activation. Either fresh stimulating cells or a lymphokine blastogenic factor (BF) were added daily to mixed cultures from the 5th to the 12th day of incubation. Whereas stimulating cells were without effect, added BF maintained both proliferative and cytotoxic activity of the cells in culture. These observations, together with previous results, were interpreted to suggest that helper cells may regulate the activation of cytotoxic lymphocytes by means of soluble mediators.

AB - MLC CML reactivity declines after approximately the 7th day of culture. The experiments described were designed to probe the reason for this decline, envisaged as due to the lack of one of the signals (HLA A,B or HLA D determinants) required for CML activation. Either fresh stimulating cells or a lymphokine blastogenic factor (BF) were added daily to mixed cultures from the 5th to the 12th day of incubation. Whereas stimulating cells were without effect, added BF maintained both proliferative and cytotoxic activity of the cells in culture. These observations, together with previous results, were interpreted to suggest that helper cells may regulate the activation of cytotoxic lymphocytes by means of soluble mediators.

UR - http://www.scopus.com/inward/record.url?scp=0017345847&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0017345847&partnerID=8YFLogxK

M3 - Chapter

AN - SCOPUS:0017345847

VL - 128 C

SP - 65

EP - 66

BT - COLLECT.ANN.INST.PASTEUR

ER -

REGULATION DE L'ACTIVATION DES CELLULES CYTOTOXIQUES PAR L'INTERMEDIAIRE DES LYMPHOKINES

Abstract

ASJC Scopus subject areas

Other files and links

Fingerprint

Cite this