TY - JOUR
T1 - The prospect of gene therapy for prostate cancer
T2 - Update on theory and status
AU - Koeneman, Kenneth S.
AU - Hsieh, Jer Tsong
PY - 2001/9/5
Y1 - 2001/9/5
N2 - Molecularly based novel therapeutic agents are needed to address the problem of locally recurrent, or metastatic, advanced hormone-refractory prostate cancer. Recent basic science advances in mechanisms of gene expression, vector delivery, and targeting have rendered clinically relevant gene therapy to the prostatic fossa and distant sites feasible in the near future. Current research and clinical investigative efforts involving methods for more effective vector delivery and targeting, with enhanced gene expression to selected (specific) sites, are reviewed. These areas of research involve tissue-specific promoters, transgene exploration, vector design and delivery, and selective vector targeting. The 'vectorology' involved mainly addresses selective tissue homing with ligands, mechanisms of innate immune system evasion for durable transgene expression, and the possibility of repeat administration.
AB - Molecularly based novel therapeutic agents are needed to address the problem of locally recurrent, or metastatic, advanced hormone-refractory prostate cancer. Recent basic science advances in mechanisms of gene expression, vector delivery, and targeting have rendered clinically relevant gene therapy to the prostatic fossa and distant sites feasible in the near future. Current research and clinical investigative efforts involving methods for more effective vector delivery and targeting, with enhanced gene expression to selected (specific) sites, are reviewed. These areas of research involve tissue-specific promoters, transgene exploration, vector design and delivery, and selective vector targeting. The 'vectorology' involved mainly addresses selective tissue homing with ligands, mechanisms of innate immune system evasion for durable transgene expression, and the possibility of repeat administration.
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U2 - 10.1097/00042307-200109000-00007
DO - 10.1097/00042307-200109000-00007
M3 - Review article
C2 - 11493770
AN - SCOPUS:0034866627
SN - 0963-0643
VL - 11
SP - 489
EP - 494
JO - Current opinion in urology
JF - Current opinion in urology
IS - 5
ER -