The promise of immunotherapy in genitourinary malignancies

Tian Zhang, Andrew J. Armstrong, Daniel J. George, Jiaoti Huang

Research output: Contribution to journalReview articlepeer-review

3 Scopus citations


A broad understanding of the tumor immune landscape has led to a revolution of immune checkpoint inhibitors in the treatment of multiple cancer types. In genitourinary malignancies, immune checkpoint inhibitors have improved outcomes for patients with metastatic renal cell carcinoma and metastatic urothelial carcinoma; however, these treatments have not yet proven broadly beneficial for patients with metastatic prostate cancer. Numerous prospective trials are ongoing to further improve outcomes with immunotherapy combinations and for biomarker development to predict benefit from immune checkpoint inhibition. This perspective article highlights our current immunotherapy approaches in each of the genitourinary malignancies and the ongoing clinical trials that may inform our future treatments in renal, urothelial, and prostate cancers.

Original languageEnglish (US)
Pages (from-to)97-101
Number of pages5
JournalPrecision Clinical Medicine
Issue number3
StatePublished - Dec 1 2018
Externally publishedYes


  • Immune checkpoint inhibition
  • Prostate cancer
  • Renal cell carcinoma
  • Urothelial carcinoma

ASJC Scopus subject areas

  • Medicine(all)


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