The Primary Cilium: Keeper of the Key to Cell Division

Junmin Pan; William Snell

doi:10.1016/j.cell.2007.06.018

The Primary Cilium: Keeper of the Key to Cell Division

Junmin Pan, William Snell

Research output: Contribution to journal › Short survey › peer-review

131 Scopus citations

Abstract

Assembly of the nonmotile primary cilium of vertebrate cells requires one of the centrioles of the centrosome. A cluster of new studies, including one in this issue of Cell by Pugacheva et al. (2007), reveal that ciliary assembly proteins influence cell-cycle progression and that a centrosomal "mitotic kinase" promotes ciliary disassembly. The link between the cell cycle and the primary cilium may reflect a requirement for liberation of the ciliary centriole to allow the centrosome to form the mitotic spindle.

Original language	English (US)
Pages (from-to)	1255-1257
Number of pages	3
Journal	Cell
Volume	129
Issue number	7
DOIs	https://doi.org/10.1016/j.cell.2007.06.018
State	Published - Jun 29 2007

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

Access to Document

10.1016/j.cell.2007.06.018

Cite this

@article{39a5a7ad47564159bead69c754ac0c12,

title = "The Primary Cilium: Keeper of the Key to Cell Division",

abstract = "Assembly of the nonmotile primary cilium of vertebrate cells requires one of the centrioles of the centrosome. A cluster of new studies, including one in this issue of Cell by Pugacheva et al. (2007), reveal that ciliary assembly proteins influence cell-cycle progression and that a centrosomal {"}mitotic kinase{"} promotes ciliary disassembly. The link between the cell cycle and the primary cilium may reflect a requirement for liberation of the ciliary centriole to allow the centrosome to form the mitotic spindle.",

author = "Junmin Pan and William Snell",

year = "2007",

month = jun,

day = "29",

doi = "10.1016/j.cell.2007.06.018",

language = "English (US)",

volume = "129",

pages = "1255--1257",

journal = "Cell",

issn = "0092-8674",

publisher = "Cell Press",

number = "7",

}

TY - JOUR

T1 - The Primary Cilium

T2 - Keeper of the Key to Cell Division

AU - Pan, Junmin

AU - Snell, William

PY - 2007/6/29

Y1 - 2007/6/29

N2 - Assembly of the nonmotile primary cilium of vertebrate cells requires one of the centrioles of the centrosome. A cluster of new studies, including one in this issue of Cell by Pugacheva et al. (2007), reveal that ciliary assembly proteins influence cell-cycle progression and that a centrosomal "mitotic kinase" promotes ciliary disassembly. The link between the cell cycle and the primary cilium may reflect a requirement for liberation of the ciliary centriole to allow the centrosome to form the mitotic spindle.

AB - Assembly of the nonmotile primary cilium of vertebrate cells requires one of the centrioles of the centrosome. A cluster of new studies, including one in this issue of Cell by Pugacheva et al. (2007), reveal that ciliary assembly proteins influence cell-cycle progression and that a centrosomal "mitotic kinase" promotes ciliary disassembly. The link between the cell cycle and the primary cilium may reflect a requirement for liberation of the ciliary centriole to allow the centrosome to form the mitotic spindle.

UR - http://www.scopus.com/inward/record.url?scp=34250891981&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34250891981&partnerID=8YFLogxK

U2 - 10.1016/j.cell.2007.06.018

DO - 10.1016/j.cell.2007.06.018

M3 - Short survey

C2 - 17604715

AN - SCOPUS:34250891981

SN - 0092-8674

VL - 129

SP - 1255

EP - 1257

JO - Cell

JF - Cell

IS - 7

ER -

The Primary Cilium: Keeper of the Key to Cell Division

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this