The square antiprism/twisted square antiprism ratio in LnDOTA-tetraamide chelates is a critical parameter in governing water-exchange kinetics and ultimately the utility of a chelate as a PARACEST MRI contrast agent. In LnDOTA-tetraamide chelates with tertiary amides, this ratio and the rate of interconversion between these two structural isomers are found to be dramatically dependent upon the solvent and possibly other local environmental factors.
|Original language||English (US)|
|Number of pages||3|
|State||Published - Oct 4 2010|
ASJC Scopus subject areas
- Physical and Theoretical Chemistry
- Inorganic Chemistry