The origins and functions of hepatic polyploidy

Shuyuan Zhang, Yu Hsuan Lin, Branden Tarlow, Hao Zhu

Research output: Contribution to journalReview articlepeer-review

28 Scopus citations


Polyploid cells contain more than two homologous sets of chromosomes. The original observations of liver polyploidy date back to the 1940s, but functional roles for polyploid cells are still unclear. Liver polyploidy may influence regeneration, stress response, and cancer, although little evidence has established direct causal links between polyploidy and these biological phenotypes. In this review, we will introduce broad concepts about polyploidy including its distribution in nature and how polyploids form in normal and pathological situations. Then we will examine recent discoveries that have begun to clarify functionality and disease relevance of liver polyploidy. Finally, we will discuss implications and future directions of research about polyploidy in the liver.

Original languageEnglish (US)
Pages (from-to)1302-1315
Number of pages14
JournalCell Cycle
Issue number12
StatePublished - Jun 18 2019


  • Polyploidy
  • cancer
  • cell cycle
  • hepatocyte
  • liver
  • regeneration

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Biology
  • Cell Biology


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