The opposed influences of β-adrenergic stimulation and adenosine on the frequency-force relationship of isolated left atria of guinea-pigs

D. Hilgemann; R. Englert; H. J. Mensing

doi:10.1007/BF01934040

The opposed influences of β-adrenergic stimulation and adenosine on the frequency-force relationship of isolated left atria of guinea-pigs

D. Hilgemann, R. Englert, H. J. Mensing

Research output: Contribution to journal › Article › peer-review

Abstract

The normal frequency-force relationship of left guinea-pig atria can be largely suspended when strong β-adrenergic stimulation by orciprenaline is antagonized by the negative inotropic effect of adenosine, so that contraction amplitude is nearly equal at an intermediate level over a wide range of stimulation rates. Curves obtained with a new method for recording continuous frequency-force loops are presented.

Original language	English (US)
Pages (from-to)	1629-1631
Number of pages	3
Journal	Experientia
Volume	33
Issue number	12
DOIs	https://doi.org/10.1007/BF01934040
State	Published - Dec 1977

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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10.1007/BF01934040

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title = "The opposed influences of β-adrenergic stimulation and adenosine on the frequency-force relationship of isolated left atria of guinea-pigs",

abstract = "The normal frequency-force relationship of left guinea-pig atria can be largely suspended when strong β-adrenergic stimulation by orciprenaline is antagonized by the negative inotropic effect of adenosine, so that contraction amplitude is nearly equal at an intermediate level over a wide range of stimulation rates. Curves obtained with a new method for recording continuous frequency-force loops are presented.",

author = "D. Hilgemann and R. Englert and Mensing, {H. J.}",

year = "1977",

month = dec,

doi = "10.1007/BF01934040",

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AU - Englert, R.

AU - Mensing, H. J.

PY - 1977/12

Y1 - 1977/12

N2 - The normal frequency-force relationship of left guinea-pig atria can be largely suspended when strong β-adrenergic stimulation by orciprenaline is antagonized by the negative inotropic effect of adenosine, so that contraction amplitude is nearly equal at an intermediate level over a wide range of stimulation rates. Curves obtained with a new method for recording continuous frequency-force loops are presented.

AB - The normal frequency-force relationship of left guinea-pig atria can be largely suspended when strong β-adrenergic stimulation by orciprenaline is antagonized by the negative inotropic effect of adenosine, so that contraction amplitude is nearly equal at an intermediate level over a wide range of stimulation rates. Curves obtained with a new method for recording continuous frequency-force loops are presented.

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The opposed influences of β-adrenergic stimulation and adenosine on the frequency-force relationship of isolated left atria of guinea-pigs

Abstract

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