The NRSE smRNA specifies the fate of adult hippocampal neural stem cells.

Tomoko Kuwabara; Jenny Hsieh; Kinichi Nakashima; Masaki Warashina; Kazunari Taira; Fred H. Gage

doi:10.1093/nass/49.1.87

The NRSE smRNA specifies the fate of adult hippocampal neural stem cells.

Tomoko Kuwabara, Jenny Hsieh, Kinichi Nakashima, Masaki Warashina, Kazunari Taira, Fred H. Gage

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Abstract

Recently we found that the nuclear localized small modulatory double-stranded (ds) RNA (smRNA) coding NRSE sequences triggered activation of transcription of NRSE genes in adult hippocampal neural stem cells. NRSE smRNA, which are non-coding dsRNAs about 20 bp in length, reside in the nucleus and play a critical role in mediating neuronal differentiation. These smRNAs carry the sequence of NRSE/RE1, which is recognized by the NRSF/REST transcription factor. The NRSE sequences are embedded widely in the genomic region, typically in promoters of neuron-specific genes. The mechanism of action appears to be mediated through a specific interaction between dsRNA and DNA/protein interaction, rather than through siRNA or miRNA. The discovery of smRNAs extends the important contribution of non-coding RNAs as key regulators of cell fate choice for adult neurogenesis.

Original language	English (US)
Pages (from-to)	87-88
Number of pages	2
Journal	Nucleic acids symposium series (2004)
Issue number	49
DOIs	https://doi.org/10.1093/nass/49.1.87
State	Published - 2005

ASJC Scopus subject areas

Medicine(all)

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title = "The NRSE smRNA specifies the fate of adult hippocampal neural stem cells.",

abstract = "Recently we found that the nuclear localized small modulatory double-stranded (ds) RNA (smRNA) coding NRSE sequences triggered activation of transcription of NRSE genes in adult hippocampal neural stem cells. NRSE smRNA, which are non-coding dsRNAs about 20 bp in length, reside in the nucleus and play a critical role in mediating neuronal differentiation. These smRNAs carry the sequence of NRSE/RE1, which is recognized by the NRSF/REST transcription factor. The NRSE sequences are embedded widely in the genomic region, typically in promoters of neuron-specific genes. The mechanism of action appears to be mediated through a specific interaction between dsRNA and DNA/protein interaction, rather than through siRNA or miRNA. The discovery of smRNAs extends the important contribution of non-coding RNAs as key regulators of cell fate choice for adult neurogenesis.",

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AU - Taira, Kazunari

AU - Gage, Fred H.

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The NRSE smRNA specifies the fate of adult hippocampal neural stem cells.

Abstract

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