The novel functions of ubiquitination in signaling

Lijun Sun, Zhijian J. Chen

Research output: Contribution to journalReview articlepeer-review

381 Scopus citations


Ubiquitin is best known for its function in targeting proteins for degradation by the proteasome. Recent studies have revealed several new functions of ubiquitin that are independent of proteasomal degradation. These functions include the novel signaling roles of ubiquitin in DNA repair and the activation of protein kinases such as IκB kinase. In both cases, a novel form of polyubiquitin chain linked through lysine-63 of ubiquitin plays an important regulatory role. Monoubiquitination also has signaling roles that are distinct from those of polyubiquitination, as illustrated from the studies of DNA repair. Thus, polyubiquitination and monoubiquitination have emerged as important signaling mechanisms that control diverse physiological and pathological processes.

Original languageEnglish (US)
Pages (from-to)119-126
Number of pages8
JournalCurrent Opinion in Cell Biology
Issue number2
StatePublished - Apr 2004


  • Dub
  • FA
  • Fanconi Anemia
  • PolyUb
  • TLR
  • Toll-like receptor
  • UBP
  • Ub
  • deubiquitination enzyme
  • polyubiquitin
  • ubiquitin
  • ubiquitin-specific protease

ASJC Scopus subject areas

  • Cell Biology


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